Frontotemporal Dementia by Bruce L. MillerFrontotemporal Dementia by Bruce L. Miller

Frontotemporal Dementia

byBruce L. Miller

Hardcover | September 4, 2013

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Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study ofdementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs andfigures from the leaders in the field and personal communication from the researchers driving these developments.
Bruce L. Miller, MD, is Professor of Neurology at the University of California, San Francisco (UCSF) where he holds the A.W. and Mary Margaret Clausen Distinguished Chair, teaches extensively and directs the busy UCSF dementia center. He is a behavioral neurologist focused in dementia with special interests in brain and behavior relati...
Title:Frontotemporal DementiaFormat:HardcoverDimensions:208 pages, 10 × 7 × 0.98 inPublished:September 4, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195380495

ISBN - 13:9780195380491


Table of Contents

1. History and NomenclaturePick's Disease: The Contributions of Arnold PickMaintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and ConstantinidisSplintering of Pick's Disease into Multiple SubtypesCorticobasal Degeneration (CBD) - Rebeiz, Gibbs, Riley and LangFrontal Lobar Dementia of the Non-Alzheimer Type, Dementia of the Frontal Type, Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Brun Gustafson, Neary, Bowen, Snowden, MannPrimary Progressive Aphasia (PPA): Marsel Mesulam, Norman Geschwind, John Hodges, Julie Snowden, Karalyn Patterson and Marilu Gorno-TempiniUCLA and UCSF StudiesThe Biological RevolutionGeneticsNeuropathyFTD Now: Where Are We?The FutureReferences2. The Clinical Syndrome of bvFTDOverviewCase HistoryCommentClinical Features and AnatomyGenetic and Pathological CorrelatesDifferential DiagnosisAlzheimer's DiseasePsychiatric DisordersMovement DisordersChronic Traumatic EncephalopathyOther FTD Clinical PhenotypesVascular DementiaMetabolic CausesStructural Brain AbnormalitiesTreatmentMedications used to alleviate bvFTD symptomsbvFTD: Current State and Research AdvancesReferences3. The Temporal Variant of FTDOverviewCase HistoryCommentClinical Features and AnatomyRight Temporal Lobe SyndromeCreativityGenetic and Pathological CorrelatesDifferential DiagnosisTreatmentsvPPA: Current State and Research AdvancesSemantic Knowledge and the Anterior Temporal LobesAutoimmunity, Left-Handedness, Head Trauma and svPPASummaryReferences4. Progressive Nonfluent/Agrammatic AphasiaOverviewCase HistoryCommentClinical Features and AnatomyGenetic and Patholigical CorrelatesDifferential DiagnosisTreatmentnfvPPA: Current State and Research AdvancesDiagnosis from Clinical Syndrome to Molecular DiagnosisNeurolinguistic and Neuroplasticity DiscoveriesReferences5. Related Disorders: FTD-ALSOverviewAmyotrophic Lateral SclerosisCase HistoryCommentClinical Features and AnatomyEI Escorial CriteriaGenetic and Pathological CorrelatesNeuropathologyDifferential DiagnosisTreatmentFTD-ALS: Current State and Research AdvancesClinical-Pathological ConsiderationsMolecular ConsiderationsReferences6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear PalsyOverviewCorticobasal Syndrome (CBS) and Corticobasal Degeneration (CBD)Case HistoryClinical Features and AnatomyGenetic and Pathological CorrelatesDifferential DiagnosisTreatmentProgressive Supranuclear Palsy (PSP)Case HistoryClinical Features and AnatomyGenetic and Pathological CorrelatesDifferential DiagnosisTreatmentCBD and PSP: Current State and Research AdvancesClinical DilemmasNew Discoveries on the Pathogenesis of CBD, PSP and other TauopathiesNeuroimagingBasic Biological AdvancesClinical Trials for TauopathiesReferences7. A Primer of FTLD NeuropathologyGeneral FeaturesOverview of Tau-Related Neuropathology in FTLDOverview of TDP-43 and FUS Related Neuropathology in FTLD Gross Anatomical and Microscopic Changes in FTLDTau AggregatesPick's DiseasePSP and CPDArgyrophilic Grain DiseaseFTLD with Ubiquitin- and TDP-43-positive InclusionsFTLD with Tau and TDP-43-Negative but FUS-Positive InclusionsSQSTM1 and FTLDDementia Lacking Distinctive Histopathology (DLDH)Special Features of FTLD PathologyHippocampal SclerosisVon Economo NeuronsFTLD Neuropathology: Current State and Research AdvancesWhat is the Role of TDP-43 in Non-FTLD Degenerative Conditions: Alzheimer's Disease and Chronic Traumatic Encephalopathy?Basic Mechanisms in TDP-43, FUS and C9ORF72Does FTLD Spread in a Prion-like Fashion?FTD Pathology GlossaryReferences8. FTD GenesOverviewGenes Implicated in FTDMAPTGRNC9ORF72Valosin-containing-Protein ATPase (VCP)TARDBPFUSCHMP2BSQSTM1 and Ubiquilin 2Genes That Modify FTD ExpressionManagement and Genetic CounselingReferences9. FTD Reflections Upon Psychology and PhilosophyEmotionsThe SelfFree WillReligious BeliefsPsychologySocial and Emotional FunctioningExecutive Controlvon Economo NeuronsReferences10. TreatmentsDiagnosisbvFTD: Targeting Symptoms, Educating the FamilysvPPA: Targeting Symptoms, Educating the FamilynfvPPA: Targeting Symptoms and Educating the FamilyLate Stages of FTDEarly InterventionsPharmacological ReviewSelective Serotonin Reuptake Inhibitors (SSRIs)Atypical AntipsychoticsAcetylcholinesterase inhibitors (AChEIs)NMDA-Receptor AntagonistDextromethorphan Hydrobromide and Quinidine Sulfate for Pseudobulbar AffectValproic AcidGabapentinOxytocinNon-Pharmacological TherapiesComplementary and Alternative MedicineLanguage ImpairmentFuture TreatmentsTauProgranulinTDP-43, FUS, C9ORF72ConclusionsReferences