Fundamentals of Genetic Epidemiology

Hardcover | November 1, 1993

byMuin J. Khoury, Terri H. Beaty, Bernice H. Cohen

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With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles,methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and theirinteraction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific geneticindicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis).Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society.

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With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles,methods and approaches of epidemiology and gen...

Muin J. Khoury is at the Center for Disease Control. Terri H. Beaty and Bernice H. Cohen are both at Johns Hopkins University School of Hygiene and Public Health.
Format:HardcoverDimensions:400 pages, 6.3 × 9.49 × 1.34 inPublished:November 1, 1993Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195052889

ISBN - 13:9780195052886

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Table of Contents

1. Scope and Strategies of Genetic Epidemiology2. Fundamental Genetic Concepts and Approaches3. Fundamental Epidemiologic Concepts and Approaches4. Study of Genetic Traits5. Study of Genetic Factors in Disease6. Epidemiologic Approaches to Familial Aggregation7. Genetic Approaches to Familial Aggregation: Heritability8. Genetic Approaches to Familial Aggregation: Segregation Analysis9. Genetic Approaches to Familial Aggregation: Linkage Analysis10. Applications of Genetic Epidemiology in Medicine and Public Health

Editorial Reviews

"Does a very good job of introducing the field of genetic epidemiology....One interesting feature...is the way the authors weave the separate fields of genetics and epidemiology together to highlight the contribution of each to genetic epidemiology....Covers a variety of important topics well,at a level readily accessible to geneticists, epidemiologists, and statisticians. One very useful feature is the extensive reference list to work in genetic epidemiology....A very good introduction, and overview of, an increasingly important field." --Statistical Methods in Medical Research