Fundamentals of Molecular Biology

Paperback | December 31, 2010

byJ. K. Pal, S. Ghaskadbi

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Fundamentals of Molecular Biology is designed to serve as a syllabus-oriented textbook for undergraduate students of Biotechnology from JNTU, Anna University, BITS Pilani, WBUT etc. The focus is on explaining the basic concepts and techniques in molecular biology and their applicationsthereof.Starting with the definition and role of molecular biology, the book provides complete coverage of topics such as micro and macromolecule, DNA enzymes, the concept of genomes and various techniques used through its study and an overview of recombinant DNA technology and its applications. The bookdelves deeper into the subject by providing discussions on DNA replication, its damage, repair and recombination, transcription machinery in prokaryotes and eukaryotes, translation, protein folding, modifications and degradations, finally concluding with a detailed discussion on Genomics andProteomicsThe book is written in simple language aimed at helping students assimilate complex theories with ease. The text is complemented by a large number of diagrams, colour illustrations, and end-chapter questions. Key terms are highlighted in the text for students to grasp concepts quickly. Exhaustivereferences for further reading are provided at the end of every chapter for the interested reader.

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Fundamentals of Molecular Biology is designed to serve as a syllabus-oriented textbook for undergraduate students of Biotechnology from JNTU, Anna University, BITS Pilani, WBUT etc. The focus is on explaining the basic concepts and techniques in molecular biology and their applicationsthereof.Starting with the definition and role of mo...

Dr. J.K. Pal is currently Professor, Department of Biotechnology, University of Pune, Pune. In an illustrious career spanning over thirty years, he has worked in various capacities in reputed academic and research institutions in India and abroad. He has several awards, fellowships and memberships of scientific societies to his credit...

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Format:PaperbackDimensions:448 pages, 10 × 7.5 × 0.68 inPublished:December 31, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195697812

ISBN - 13:9780195697810

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Table of Contents

Preface1. The Concept1.1 Definition and importance1.2 Central dogma of molecular biology2. Chemistry and Biology of Macromolecules and Micromolecules2.1 Nucleic acids2.2 Proteins2.3 Carbohydrates2.4 Lipids2.5 MicromoleculesSummaryFurther ReadingShort answer questions3. Enzymes in Molecular Biology Research3.1 DNA modifying enzymes3.1.1 Ligase3.1.2 Polynucleotide kinase3.1.3 Phosphatases3.1.4 Polymerases3.2 DNA degrading enzymes3.2.1 Nucleases - endo and exonuclease3.2.2 Restriction endonucleaseSummaryFuther readingShort answer questions4. Techniques in Molecular Biology4.1 Essential requirements of a molecular Biology Laboratory4.2 Biophysical techniques4.2.1 Centrifugation4.2.2 Spectroscopy4.2.3 Microscopy4.2.4 NMR, CD4.2.5 X-ray crystallography4.3 Biochemical techniques4.3.1 Electrophoresis4.3.2 Chromatography4.3.3 Radiolabelling and detection4.3.4 Hybridization techniques4.3.5 Sequencing Techniques4.3.6 Polymerase chain reaction4.4 Recombinant DNA technology and its applicationsSummaryFurther readingShort answer questions5. Concept of Genome and its organization5.1 Nucleic acids as genetic materials5.2 DNA content of a cell and C-Value paradox5.3 Genome complexity - gene number, gene families, simple sequence DNA, satellite DNA5.4 Packaging of DNA- nucleosome, chromatin, structure of chromosomes5.5 Organelle genome - Mitochondria and ChloroplastSummaryFurther readingShort answer questions6. DNA Replication6.1 General features of DNA replication6.2 Replication in prokaryotes6.3 Replication in eukaryotes6.4 Termination of replication6.5 Regulation of replicationSummaryFurther readingShort answer questions7. DNA Damage and Repair and Recombination7.1 Different types of DNA damages7.2 Multiple repair pathways7.2.1 Nucleotide excision repair7.2.2 Base excision repair7.2.3 Mismatch repair7.2.4 Recombination repair7.2.5 Double strand break repair7.3 DNA Recombination7.3.1 Homologous genetic recombination7.3.2 Meiotic recombination7.3.3 Other recombination eventsSummaryFurther readingShort answer questions8. Transcriptions8.1 Transcription machinery in prokaryotes8.1.1 Initiation and elongation of transcription8.1.2 Termination of transcription8.1.3 Regulation of transcription8.2 Transcription in eukaryotes8.2.1 Promoters of eukaryotic polymerases8.2.2 Transcription factors in eukaryotes8.2.3 Transcription activators8.2.4 Chromatin and transcription8.3 Posttranscriptional events8.3.1 Splicing8.3.2 RNA editing8.3.3 Processing of mRNA at 3' end8.3.4 Processing of mRNA at 5' end8.3.5 Production of mature rRNA8.3.6 Production of mature t-RNASummaryFurther readingShort answer questions9. Translation /Protein synthesis9.1 Components of protein synthesis machinerya) mRNAb) tRNAc) Ribosomes9.2 Genetic code9.3 Mechanism of protein synthesisA. InitiationB. ElongationC. Termination9.4 In vitro cell-free translation systems9.5 Regulation of protein synthesisSummaryFurther readingShort answer questions10. Protein folding, processing and modifications, and Protein degradation10.1 Protein folding10.2 Protein processing10.3 Protein modifications10.4 Protein degradationSummaryFurtherShort answer questions11. Genomics and Proteomics11.1 Introduction to genomics11.2 Comparative genomics, genome annotation11.3 Structural genomics11.4 Functional genomics11.4.1 Studying global gene expression11.4.2 Transcriptomics and Microarrays11.4.3 Toxicogenomics11.4.4 Pharmacogenomics11.5 Human Genome project11.6 Strategies in proteomics11.7 Methodologies for proteomics11.8 Computational approach for protein-protein interactions11.9 Proteomics applications - drug development, screening of diagnostic markers, identification and characterization of novel proteinsSummaryFurther readingShort answer questions12. Glossary13. Index