G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening by P. Michael Conn

G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening

byP. Michael Conn, P. Michael Conn

Other | January 28, 2013

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers G protein coupled receptors
  • Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation

About The Author

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and O...
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Details & Specs

Title:G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual ScreeningFormat:OtherDimensions:528 pages, 1 × 1 × 1 inPublished:January 28, 2013Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012407944X

ISBN - 13:9780124079441

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Table of Contents

GPCR Modeling

  1. The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
  2. Modeling Active GPCR Conformations
  3. Molecular Modeling of Adenosine Receptors
  4. Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition
  5. Computational Design and Experimental Characterization of GPCR Segment Models

    GPCR Interactions with Other Molecules and Cross-Talk

  6. G Protein-Coupled Receptor Interaction with Small GTPases
  7. Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
  8. NMR Methods for Detection of Small Molecule Binding to RGS4
  9. Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
  10. Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
  11. cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
  12. Rhodopsin-Lipid Interactions Studied by NMR
  13. GPCR Bias

  14. Biasing the Parathyroid Hormone Receptor: RelatingIn VitroLigand Efficacy toIn VivoBiological Activity
  15. Virtual Screening

  16. Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
  17. From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands
  18. GPCR Activation

  19. Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
  20. Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
  21. Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
  22. Protein S-Nitrosylation Measurement