G Protein Coupled Receptors: Structure

Other | January 17, 2013

byP. Michael Conn, P. Michael Conn

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This new volume ofMethods in Enzymologycontinues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.



  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers G protein coupled receptors
  • Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

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This new volume ofMethods in Enzymologycontinues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual scree...

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and O...

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Format:OtherDimensions:440 pages, 1 × 1 × 1 inPublished:January 17, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123918723

ISBN - 13:9780123918727

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Table of Contents

    1. G Protein Coupled Receptors: Techniques for Probing Structure
    2. Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding
    3. Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach
    4. Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability
    5. The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors
    6. Structure of ß-Adrenergic Receptors
    7. Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors
    8. Crystallogenesis of Adenosine A2AReceptor - T4 Lysozyme Fusion Protein: A Practical Route for the Structure
    9. Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors
    10. Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs
    11. Expression of Mammalian G Protein-Coupled Receptors inCaenorhabditis Elegans
    12. Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors
    13. Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling
    14. Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers
    15. Alternative mRNA Splicing of G Protein-Coulped Receptors
    16. Functional Residues of the CB1 Cannabinoid Receptor