G Protein Coupled Receptors: Trafficking and Oligomerization

Other | January 24, 2013

byP. Michael Conn, P. Michael Conn

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This new volume ofMethods in Enzymologycontinues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs.

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers G protein coupled receptors
  • Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

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This new volume ofMethods in Enzymologycontinues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-frien...

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and O...

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Format:OtherDimensions:480 pages, 1 × 1 × 1 inPublished:January 24, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123918731

ISBN - 13:9780123918734

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Table of Contents

    GPCR Trafficking

    1. Therapeutic Rescue of Misfolded/Mistrafficked Mutants: Automation-Friendly High Throughput Assays for Identification of Pharmacoperone Drugs of GPCRs
    2. Trafficking of the Follitropin Receptor
    3. Single Molecule Imaging Technique to Study the Dynamic Regulation of GPCR Function at the Plasma Membrane
    4. GPCR Oligomerization and Receptor Trafficking
    5. b-Arrestins and G Protein-Coupled Receptor Trafficking
    6. Tracking Cell Surface Mobility of GPCRs Using α-Bungarotoxin Linked Fluorophores
    7. Regulatory Mechanism of G Protein-Coupled Receptor Trafficking to the Plasma Membrane: A Role for mRNA Localization
    8. Dissecting Trafficking and Signaling of Atypical Chemokine Receptors
    9. Trafficking Motifs

    10. Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs
    11. Identification of Endoplasmic Reticulum Export Motifs for G Protein-Coupled Receptors
    12. Amino Acid Residues of G-Protein Coupled Receptors Critical for Endoplasmic Reticulum Export and Trafficking
    13. GPCR Oligomerization

    14. G Protein-Coupled Heteromers Regulation in Disease
    15. Hetero-Oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction
    16. Bimolecular Fluorescence Complementation Analysis of G Protein-Coupled Receptor Dimerization in Living Cells
    17. G-Protein Coupled Receptor Heterodimerization in the Brain
    18. Experimental Strategies for Studying G Protein-Coupled Receptor Homo- and Heteromerization with Radioligand Binding and Signal Transduction Methods
    19. Analysis of GPCRs Dimerization Using Acceptor Photobleaching Resonance Energy Transfer Techniques
    20. Techniques for the Discovery of GPCR-Associated Protein Complexes
    21. Expression, Purification and Analysis of GProtein-Coupled Receptor Kinases
    22. Modern Methods to Investigate the Oligomerization of Glycoprotein Hormone Receptors (TSHR,LHR, FSHR)