Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Paperback | April 27, 2005

byJotun Hein, Mikkel Schierup, Carsten Wiuf

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Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course instatistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia

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Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course instatistics, population, molecular and medical genet...

Jotun Hein is a Professor of Bioinformatics Department of Statistics, University of Oxford. Mikkel Schierup and Carsten Wiuf are both at the Bioinformatics Research Center, University of Aarhus, Denmark.
Format:PaperbackDimensions:296 pages, 9.69 × 6.73 × 0.61 inPublished:April 27, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198529961

ISBN - 13:9780198529965

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Table of Contents

PrefaceThe basic coalescentFrom genealogies to sequencesTrees and topologiesExtensions to the basic coalescentThe coalescent with recombinationGetting parameters from dataLD Mapping and the coalescentHuman evolutionAppendix: Web based tools

Editorial Reviews

`The book succeeds very well in engendering enthusiasm for developing mathematical models and methods which can be applied to DNA sequence data, and it introduces the reader to open research problems.'Mathematical Reviews