Genes and Mechanisms in Vertebrate Sex Determination by Gerd SchererGenes and Mechanisms in Vertebrate Sex Determination by Gerd Scherer

Genes and Mechanisms in Vertebrate Sex Determination

byGerd SchererEditorMichael Schmid

Paperback | October 3, 2013

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Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.

Title:Genes and Mechanisms in Vertebrate Sex DeterminationFormat:PaperbackDimensions:205 pagesPublished:October 3, 2013Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3034877838

ISBN - 13:9783034877831

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Table of Contents

The one-to-four rule and paralogues of sex-determining genes.- Genes essential for early events in gonadal development.- Sry, Sox9 and mammalian sex determination.- DAX-1, an "antitestis" gene.- Sex chromosomes and sex determining genes: insights from marsupials and monotremes.- An overview of factors influencing sex determination and gonadal development in birds.- Temperature-dependent sex determination and gonadal differentiation in reptiles.- Sex chromosomes, sex-linked genes, and sex determination in the vertebrate class Amphibia.- Endocrine and environmental aspects of sex differentiation in gonochoristic fish.