Genetic Mapping Of Disease Genes

Hardcover | September 16, 1997

byIvar-harry PawlowtzkiEditorJ. G. Edwards, Elizabeth A. Thompson

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A state-of-the-art reference, Genetic Mapping of Disease Genes presents a detailed account of the new methodical approaches to gene mapping. It provides completely up-to-date information and comprehensive coverage of research in this field, and includes contributions from the leading experts. The book gives a broad overview of the genetic mapping involved in inherited diseases and discusses the shortcomings of established mapping procedures.The book will be essential reading for all researchers and postgraduate research students in molecular genetics, clinical genetics, and molecular biology, but also those involved in ophthalmology, public health, medical statistics, and mathematics. Key Features* The volume covers:* Introduction and History* Linkage in Dominant Recessive and Oligogenic Disease* Model Free Non-Parametric Methods* Tools for Gene Mapping * Applications

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From the Publisher

A state-of-the-art reference, Genetic Mapping of Disease Genes presents a detailed account of the new methodical approaches to gene mapping. It provides completely up-to-date information and comprehensive coverage of research in this field, and includes contributions from the leading experts. The book gives a broad overview of the gene...

From the Jacket

The rapid progress in the field of gene mapping over the last decade has advanced our understanding of the underlying causes of inherited disease.This book, edited by leading figures in clinical genetics and pedigree anaiysis, presents a detailed account of new methodological approaches.Written by internationally acclaimed experts the ...

Format:HardcoverDimensions:288 pages, 9 × 6 × 0.98 inPublished:September 16, 1997Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0122327357

ISBN - 13:9780122327353

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Table of Contents

Introduction and History:
J.H. Edwards, Introduction.
A.W.F. Edwards, The Early History of the Statistical Estimation of Linkage.
Linkage in Dominant, Recessive, and Polygenic Disease:
N.E. Morton and P. Lio, Oligogenic Linkage and Map Integration.
J. Ott, Genetic Mapping in Complex Disorders.
J.H. Edwards, Recessive Disease and Allelic Association.
T. Grimm, Mutation-Selection-Equilibria, Genetic Models, and Linkage Analysis.
D. Stephens and C.A.B. Smith, Simple Likelihood and Probability Calculations for Linkage Analysis.

Editorial Reviews

"These contributions, from some of the most eminent geneticists of our day, are dazzlingly heterogenous in both style and content. They range from the thorough and methodical to the allusive and almost whimsical, from a fascinating account of the earliest history of linkage analysis to descriptions of novel methods whose status in the field is as yet unclear...I would recommend this book to anyone with an interest in this field."--ANNALS OF HUMAN GENETICS