Genetic Susceptibility to Infectious Diseases

Hardcover | January 15, 2008

EditorRichard A. Kaslow, Janet McNicholl, Adrian V. S. Hill

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Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) conceptsand methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other workon the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.

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Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) conceptsand methods, 2) genes and pathophysiologic mec...

Richard Kaslow is a Professor of Epidemiology and International Health, Medicine, and Microbiology at the University of Alabama. Janet McNicholl is with the Centers for Disease Control and Prevention. Adrian Hill is with the Wellcome Trust Centre for Human Genetics at the University of Oxford.

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Format:HardcoverDimensions:464 pages, 9.9 × 7.3 × 1.1 inPublished:January 15, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195174909

ISBN - 13:9780195174908

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Table of Contents

Section I: Methods and Tools1. Genetic Epidemiology of Infectious Disease2. Laboratory Analysis of Genetic Variation3. Mouse Models for Geentic Susceptibility to Infection in HumansSection II: Immune Response Genes and Infection. 4. MHC Class I and Related Genes5. MHC Class II and Related Genes6. MHC Class I Polypeptide-Related Sequence A and B (MICA and MICB) Genes7. Killer Immunoglobulin-Like Receptor and Related Genes8. Red Blood Cell Genes9. Immunoglobulin (Fc) Receptor and Related Genes10. Mannose-Binding Lectin Genes11. Complement Genes13. Metal Transport Genes14. Tumor Necrosis Factor and Related Genes15. Cytokine Genes I (IL10, IL6, IL4, and the IL1 Family)16. Cytokine Genes II (IFNG, IL12 and Their Receptor Genes)17. Chemokine Receptor and Ligand GenesSection III: Genetic Determinants of Infectious Diseases and Response to Vaccines. 18. Immune Deficiency Disorders19. Human Immunodeficiency Virus, Type 1 (HIV-1) and Acquired Immunodeficiency Syndrome20. Human T Lymphotropic Virus, Type 1 (HTLV-1)-Associated Diseases21. Hepatitis B and C22. Tuberculosis, Leprosy and Other Mycobacterial Diseases23. Diseases Due to Selected Encapsulated Bacteria24. Malaria25. Leishmaniasis26. Schistosomiasis27. Immune Response to Vaccines