Genetics of Bone Biology and Skeletal Disease by Rajesh V. ThakkerGenetics of Bone Biology and Skeletal Disease by Rajesh V. Thakker

Genetics of Bone Biology and Skeletal Disease

byRajesh V. Thakker, Rajesh V. Thakker, Michael P. Whyte...

Other | December 31, 2012

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This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder.

  • Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles.
  • Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease
  • Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays
  • For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.
Title:Genetics of Bone Biology and Skeletal DiseaseFormat:OtherDimensions:634 pages, 1 × 1 × 1 inPublished:December 31, 2012Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123878306

ISBN - 13:9780123878304


Table of Contents

Part I: General Background to Bone Biology

  1. Biology of Bone and Cartilage
  2. Brendan Boyce, Michael Zuscik, Lianping Xing

  3. Overview of Bone Structure and Strength
  4. Mary L. Bouxsein

  5. Overview of Joint and Cartilage Biology
  6. Frank Luyten and Rik JU Lories

  7. Integrating Endocrine and Paracrine Influences on Bone: Lessons from Parathyroid Hormone and Parathyroid Hormone-related Protein
  8. T. John Martin and Natalie A. Sims

  9. Energy Homeostasis and Neuronal Regulation of Bone Remodeling
  10. Gerard Karsenty, Mathieu Ferron and Franck Oury

  11. Neuropeptide Y and Bone Regulation
  12. Paul A. Baldock

    Part II: General Background to Genetics

  13. Genome-wide Association Studies
  14. Matthew Brown and Emma L. Duncan

  15. Genomic Profiling in Bone
  16. Gabriela G. Loots and Bryan D. Hudson

  17. Copy Number Variation
  18. Hong-Wen Deng, Tie-Lin Yang, Yan Guo and Christopher J. Papasian

  19. Prospects of Gene Therapy
  20. Brendan Lee, Merry ZC Ruan and Kilian Guse

  21. Pharmacogentics and Pharmacogenomics of Osteoporosis: Personalized Medicine Outlook
  22. Tuan V. Nguyen and John A. Eisman

  23. Genetic Testing & Counselling
  24. Ingrid A. Holm, Christina M. Jacobsen, Yiping Shen and Stephanie J. Brewster

  25. Mouse models: Approaches to Generatingin vivoModels for Hereditary Disorders of Mineral and Skeletal Homeostasis
  26. Sian E. Piret and Rajesh V. Thakker

  27. Fetal Control of Calcium and Phosphate Homeostasis - Lessons from Mouse Models
  28. Christopher S. Kovacs

  29. Control of Skeletal Homeostasis during Pregnancy and Lactation - Lessons from Physiological Models
  30. Christopher S. Kovacs

    Part III: Disorders of Bone and Joint

  31. Osteogenesis Imperfecta
  32. Joan Marini and M. Helen Rajpar

  33. Osteoporosis Genes Identified by Genome-wide Association Studies
  34. Andre Uitterlinden and Fernando Rivadenerira

  35. Osteoarthritis - Genetic Studies of Monogenic and Complex Forms
  36. Ana M. Valdes

  37. Paget's Disease
  38. Stuart H. Ralston and Omar M.E. Albagha

  39. Heritable Disorders of RANKL, OPG, RANK and NF-KB Signalling
  40. Michael Whyte

  41. Skeletal Dysplasias
  42. William G. Cole

  43. Hypophosphatasia
  44. Michael P. Whyte

  45. Sclerosing Bone Disorders
  46. Bram Perdu and Wim Van Hul

  47. Fibrodysplasia (Myositis) Ossificans Progressiva
  48. Andria L. Culbert, Salin A. Chakkalakal, Michael R. Convente, Vitali Y. Lounev, Frederick S. Kaplan and Eileen M. Shore

    Part IV: Parathyroid and Related Disorders

  49. Hyperparathyroidism
  50. Andrew Arnold and Jessica Costa-Guda

  51. Hypoparathyroidism
  52. Rajesh V. Thakker

  53. Gsa, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune-Albright Syndrome
  54. Lee S. Weinstein, Allen M. Spiegel and Michael Collins

  55. Genetic disorders affecting PTH/PTHrP receptor function
  56. Harald Jueppner and Caroline Silve

  57. Genetically Determined Disorders of the Calcium-Sensing Receptor
  58. Edward M. Brown and Ogo I. Egbuna

  59. Multiple Endocrine Neoplasia Type 1 (MEN1)
  60. Rajesh V. Thakker

  61. Multiple Endocrine Neoplasia Type 2 (MEN2)
  62. Bruce Robinson, Rory Clifton-Bligh and Matti Gild

    Part V: Vitamin D and Renal Disorders

  63. Heritable Renal Phosphate Wasting Disorders
  64. Marc K. Drezner

  65. Genetic Disorders of Vitamin D Synthesis and Action
  66. David Feldman, Peter Malloy and Walter L. Miller

  67. Renal Fanconi Syndrome, Dent's Disease and Bartter's Syndrome
  68. Olivier Devuyst and Takashi Igarashi

  69. Inherited Magnesium Disorders
  70. Scott J. Schurman, Dhruval Patel, Anil Singh and Steven J. Scheinman

  71. Genetic Hypercalciuria: A Major Risk Factor in Kidney Stones

David Bushinsky and Orson W. Moe