Genetics of Cellular, Individual, Family, and Population Variability

Hardcover | April 1, 1994

EditorCharles F. Sing, Craig L. Hanis

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The objective of this book is to review the impact of genetic variation on risk of human disease at the different major levels of organization: cells, individuals, families, and populations. The volume begins with a discussion of sources and rates of mutation which ultimately give rise to thevast amount of extant genetic variation. This is followed by presentations of current understanding of how genetic variation is maintained within and among populations. The volume ends with discussions of the implications of such variation for understanding the evolution of our species. Thiscollection gives an unusually broad treatment of the subject, with chapters from some of the leading workers in the field. James Neel's chapter on human consanguinity effects and M. Otake's on the genetic effects of radiation associated with the dropping of the Hiroshima and Nagasaki atomic bombsshould be singled out for special emphasis. As an up-to-date overview of ongoing research, this work will be of interest to a wide range of workers in the fields of human population genetics, evolution, and epidemiology.

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The objective of this book is to review the impact of genetic variation on risk of human disease at the different major levels of organization: cells, individuals, families, and populations. The volume begins with a discussion of sources and rates of mutation which ultimately give rise to thevast amount of extant genetic variation. Th...

Charles F. Sing is at University of Michigan Medical School. Craig L. Hanis is at University of Texas Health Science Center at Houston.

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Format:HardcoverDimensions:320 pagesPublished:April 1, 1994Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195066251

ISBN - 13:9780195066258

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Table of Contents

1. K.M. Weiss: Medieval mappaemundi and the Conceptual Map of Genetics: Changing Views of Cancer Biology and Other Thoughts2. A. Chakravarti: Impact of Genetic, Somatic, and Epigenetic Variation on Phenotype3. R.E. Ferrell: Impact of Genetic Variation in Individuals--Clonal Phenotypes Other Than Cancer4. J.V. Neel: Human Consanguinity Effects Revisited: Why is Measurable Impact of Inbreeding So Small?5. M. Otake: Genetic Risks from Exposure to the Atomic Bombs: Hiroshima and Nagasaki6. E. Boerwinke and D.M. Hallman: Genotype by Environment Interaction--It's a Fact of Life7. S.P. Daiger and S.H. Blanton: Problems and Pitfalls in Linkage Mapping of Human Genetic Diseases: Illustrations from Autosomal Dominant Retinitis Pigmentosa (ADRP)8. J.W. MacCluer: Applications of Pedigree Analysis to Animal Models for Complex Diseases9. C.F. Sing and S. Reilly: Genetics of Common Diseases that Aggregate, but do not Segregate, in Families10. A.G. Knudson, Jr.: Pathodemes: Heredity, Environment, and Populations of Disease Susceptibility11. C.L. Hanis: Genetic Inferences for Epidemiologic Investigations12. R. Chakroborty: Generalized Occupancy Problem and Its Applications in Population Genetics13. B.R. Levin: The Maintenance of Genetic Variation in Bacterial Populations14. P.E. Smouse: Some Theoretical Predictions for Electrophoretic Polymorphisms Maintained by Balancing Selection15. E.J.E. Szathmary: Application of Our Understanding of Genetic Variation in Native North America16. Genetic Variation and Evolution of Human Populations, M. Nei, G. Livshits, and T. Ota17. W.-H. Li, W. Xiong, S.-W. Liu, and L. Chan: Nucleotide Diversity in Man and Evidence for the Absence of a Severe Bottleneck during Human Evolution18. J.N. Spuhler: Population Genetics and Evolution in the Genus Homo in the Last Two Million Years

Editorial Reviews

"Many new findings and insights into recent approaches to the ever-expanding study of human genetic variation are provided. ... The editors have struck a balance between field and laboratory data." -- American Journal of Human Biology