Genome Instability in Cancer Development by Erich A. NiggGenome Instability in Cancer Development by Erich A. Nigg

Genome Instability in Cancer Development

EditorErich A. Nigg

Hardcover | October 24, 2005

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Most human cancers display a myriad of genetic changes, a characteristic often attributed to genome instability. Cytogenetic studies have long identified chromosomal aberrations as a hallmark of human tumours, but the causes and consequences of genomic defects in tumours still remain to be fully understood. In particular, the role of genome instability in the development of human cancers as well as its relevance to treatment paradigms continue to evoke intense debate. To address these critical issues it is clearly important to understand the mechanisms that give rise to genome instability. This book reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. Reflecting recent discoveries and ongoing research, it discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Moreover, it summarises our current understanding of the various defects that may allow cancer cells to rapidly accumulate critical mutations and evolve, through processes reminiscent of Darwinian selection, an increasingly aggressive behaviour. Hopefully, this book will stimulate thought, discussion and experimentation, and serve as a rich source of information for a wide audience, including advanced students, researchers and clinical oncologists.
Title:Genome Instability in Cancer DevelopmentFormat:HardcoverDimensions:528 pagesPublished:October 24, 2005Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1402037635

ISBN - 13:9781402037634

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Table of Contents

Part 1. The Problem of Genome Instability 1.1. The Multiplicity of Mutations in Human Cancers by Ranga N. Venkatesan and Lawrence A. Loeb1.2. Monitoring chromosome rearrangements by Michael R. Speicher Part 2. DNA Repair and Mutagenesis 2.1. Nucleotide excision repair and its connection with cancer and ageing by Jaan-Olle Andressoo, Jan H.J. Hoeijmakers and Harm de Waard2.2. DNA mismatch repair and colon cancer by Giancarlo Marra and Josef Jiricny2.3. Base excision repair by Lisiane B. Meira, Nicholas E. Burgis and Leona D. Samson2.4. DNA double strand break repair by Penny A. Jeggo2.5. Translesion synthesis and error-prone polymerases by Catherine M. Green and Alan R. Lehmann Part 3. Cell Cycle Progression and Chromosome Aberrations 3.1. The INK4A/ARF network - cell cycle checkpoint or emergency brake? By Ana Gutierrez del Arroyo and Gordon Peters3.2. DNA replication and genomic instability by Wenge Zhu, Tarek Abbas and Anindya Dutta3.3. The dream of every chromosome: equal segregation for a healthy life of the host by Tomohiro Matsumoto and Mitsuhiro Yanagida3.4. Telomere structural dynamics in genome integrity control and carcinogenesis by Roger A. Greenberg and K. Lenhard Rudolph3.5. Gene amplification mechanisms by Michelle Debatisse and Bernard Malfoy3.6. DNA methylation and cancer-associated genetic instability by Melanie Ehrlich3.7. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer by Wilma L. Lingle, Kara Lukaswiewicz and Jeffrey L. Salisbury Part 4. Genome Integrity Checkpoints 4.1. Mammalian DNA damage response pathway by Zhenkun Lou and Junjie Chen4.2. ATM and cellular response to DNA damage by Martin F Lavin, Sergei Kozlov, Nuri Gueven, Cheng Peng, Geoff Birrell, Phillip Chen and Shaun Scott4.3 Kinetochore function, chromosome segregation and the spindle assembly checkpoint by Tim J. Yen and Gary D. Kao