Genomic Biomarkers For Pharmaceutical Development: Advancing Personalized Health Care by Yihong YaoGenomic Biomarkers For Pharmaceutical Development: Advancing Personalized Health Care by Yihong Yao

Genomic Biomarkers For Pharmaceutical Development: Advancing Personalized Health Care

byYihong YaoEditorBahija Jallal, Koustubh Ranade

Hardcover | August 14, 2013

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Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Careprovides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development.

With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.

  • Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases
  • Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs
  • Authored by leading international experts from industry and academia
PhD, MedImmune, Gaithersburg, MD
Title:Genomic Biomarkers For Pharmaceutical Development: Advancing Personalized Health CareFormat:HardcoverDimensions:208 pages, 9.25 × 7.5 × 0.98 inPublished:August 14, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123973368

ISBN - 13:9780123973368

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Table of Contents

1. Application of TS in clinical development
2. Personalized Healthcare (PHC) in cancer
3. PHC in autoimmune diseases
4. PHC in respiratory diseases
5. miRNA as potential Diagnostic Marker
6. Toxicogenomics
7. Translating Biomarker Discovery into Companion Diagnostics Through Validation and Regulatory Consideration

Editorial Reviews

"After a good overview of the knowledge in this area, excellent chapters describe how genomics is applicable to some common diseases. The book covers important methodology required to advance personalized medicine and clearly outlines challenges to moving this field forward." Rating: 3, April 25, 2014