Genomic Imprinting

Paperback | October 1, 1997

EditorWolf Reik, Azim Surani

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Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomicimprinting have begun to be answered. This volume reviews the latest exciting developments, with full citations of all of the key bibliography. It also discusses the major unanswered questions in this field and outlines directions for future research. Topics covered in Genomic Imprinting include:the role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomicimprinting for fetal development; genomic imprinting in the mouse; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the PraderWilli/Angelman syndrome region on human chromosome 15; convergent themes in Xchromosome inactivation and autosomal imprinting; and evolutionary theories of genomic imprinting.

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From the Publisher

Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomicimprinting have begun to be answered. This volume r...

Dr Wolf Reik, The Babraham Institute, Babraham Hall, Babraham, Cambridge CB2 4AT. Email: wolf.reik@bbsrc.ac.uk Professor Azim Surani, Wellcome/CRC Institute, Cambridge
Format:PaperbackDimensions:268 pages, 9.69 × 7.44 × 0.59 inPublished:October 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199636257

ISBN - 13:9780199636259

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Table of Contents

Role of DNA methylation in mammalian developmentDevelopmental regulation of imprinting by DNA methylationImprinting at the mouse and human IGF2R lociFunction and epigenetic modification of the imprinted H19 geneThe imprinted insulin-like growth factor 2 geneConsequences of genemoic imprinting for fetal developmentGenomic imprinting in the mouse: possible final analysisSystematic approaches for the identification of imprinted genesGenomic imprinting as a developmental process disturbed in cancerImprinting in the Prader-Willi/Angelman syndrome region on human chromosome 15Convergent themes in X chromosome inactivation and autosomal imprintingEvolutionary theories of genomic imprinting

Editorial Reviews

"The term 'genomic imprinting' is used in various ways, but it is usually applied to situations in which genetic material behaves in one way when inherited maternally and another way when inherited paternally. This volume is concerned with cases in which a gene is expressed almost exclusively fromone allele during some developmental stages. Such genes are of interest to biologists with a variety of orientations. . . . In twelve chapters, this volume presents a wide variety of information relevant to parent-of-origin effects in mice and humans. . . . The chapters fit together nicely, with fewof the awkward gaps and unhelpful redundancies that plague many such multiauthored monographs. . . . ÝT¨he book should be accessible to biologists who are unfamiliar with imprinting, yet it will be valuable even to workers in this field."--The Quarterly Review of Biology"The book can be recommended for those wishing for an accessible introduction to the subject of the molecular mechanisms of genomic imprinting."--American Journal of Human Biology"ÝG¨enomic imprinting . . . hypothesizes that it is not sufficient to inherit two copies of certain genes and/or chromosomal regions: normal development requires that one copy be paternally derived while the other be maternally derived. Situations that do not conform to this pattern of inheritancecould potentially lead to the complete or almost complete silencing of the transcription from one allele . . . Wolf Reik and Azim Surani . . . have edited a very useful primer . . . designed for a reader with a basic background in molecular biology and genetics. . . . One of the outstanding featuresof this book is that each chapter canstand alone . . . This makes it a great resource for genetics students and faculty. . . . ÝT¨he index and table of contents appear inclusive. . . . This book represents an excellent summary of the field . . . and provides a foundation for understanding thisexciting and dynamic area of research."--The Journal of the Association of Genetic Technologists"This volume reviews the latest developments in this field and points the way to areas of future research. The work contains 12 chapters written by experts. Diagrams, photographs, tables and graphs supplement the text. An index is provided." -- Biosis, Vol 50, Issue 7, July 22, 1998