Genomics and Health in the Developing World

Hardcover | May 11, 2012

byDhavendra Kumar

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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation - with particular emphasis on medical and health issues - in the emerging economies and countries of the developing world. With sectionsdedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights theimportance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address:* Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent* The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide * Rising ethical and legal concerns of medical genetics in the developing world* Social, cultural, and religious issues related to genetic diseases across continentsBoth timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.

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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation - with particular emphasis on medical and health issues - in the emerging economies and countries of the developing world. With sectionsdedicated to fundamtals of genetics and genomics,...

Dhavendra Kumar, MD, FRCP, FACMG, is Professor at the University of Glamorgan, and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom.

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Format:HardcoverDimensions:1536 pages, 8.9 × 10.98 × 2.4 inPublished:May 11, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195374754

ISBN - 13:9780195374759

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Table of Contents

ContributorsPart I: Genomics in Medicine and Health-General1. Dhavendra Kumar: Genes and Genomes in Health and Disease: An Introduction2. Richard G.H. Cotton: The Human Variome Project and the Developing World3. Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar: Human Genomic Variation Initiatives in Emerging Economies and Developing Countries4. Dhavendra Kumar: The Genomic Map of Population Diversity in Asia5. Charles Rotimi and Lynn Jorde: Ancestry, Disease and Variable Drug Response in the Genomic Era6. Billie-Jo Hardy, B.atrice S.guin, Federico Goodsaid, Gerardo Jiminez-S nchez, Peter A. Singer, and Abdallah S. Daar: The Next Steps for Genomic Medicine: Challenges and Opportunities for the Developing World7. Alastair Kent: Consumer Perspectives on Genomics and Healthcare8. Dhavendra Kumar: Transcultural Perspectives on Genetics and Genomics9. Aida I. Al-Aqeel: Medical Genetics and Genomics Research in the Muslim World10. Minakshi Bhardwaj: The Progress of Genomics in the Developing World: Rising Social, Economic, and Ethical Concerns11. Alan H. Bittles and Michael L. Black: Genetic Outcomes of Consanguineous Marriages12. Colin A. Johnson and Eamonn R. Maher: Autosomal Recessive Conditions and Autozygosity Mapping13. Susana G. Campino and Taane G. Clark: Genetic Contribution to Malaria Susceptibility and Resistance14. Lucio Luzzatto: Glucose 6-Phosphate Dehydrogenase Deficiency: Genetics, Pharmacogenetics, and Malaria Selection15. Tikki Pang: Infections, Genomics, and Global Public Health16. Rino Rappuoli: Microbial Genomics and Global Health17. Warren E. Hochfeld, Sahle M. Asfaha, Marco Alessandrini, Tyren M. Dodgen, Renier Myburgh, Arinda Eloff, and Michael S. Pepper: Pharmacogenetics and Pharmacogenomics in the Developing World18. Jim Kaput: Nutrigenomic Research in World Populations19. Dhavendra Kumar and Joel Cohen: Transgenic Foods and Nutritional Health in Developing Countries20. David J. Weatherall: The Burden of Inherited Disease in the Developing World: The Example of Inherited Blood Diseases21. Chun Yo Lok, Alison T. Merryweather-Clarke, and Kathryn J.H. Robson: Health Implications of Inherited Disorders of Iron Overload22. Dwaipayan Bharadwaj, Nikhil Tandon, and Anubha Mahajan: Inherited Factors in Diabetes Mellitus and Related Metabolic Disorders in the Developing World23. Jessica Buxton, Julia El-Sayed Moustafa, Haya Al-Saud, and Alexandra Blakemore: Global Health Implications of Genetic Studies of Obesity and Type 2 Diabetes24. Deepak Bhatnagar: Health Implications of Familial Hyperlipidemia25. Wendy Jones and Anand Saggar: Global Health Implications of Inherited Renal Diseases26. Dhavendra Kumar: The Burden of Congenital Anomalies on Global Health27. Tiziana Cogliati, James Friedman, Norimoto Gotoh, Neeraj Agarwal, and Anand Swaroop: Inherited Eye Diseases in Developing Countries28. Rodney J. Pollitt: Principles and Practice of Newborn Screening-The Lessons from the Developed World29. Peter Lunt: Diagnostic Laboratory Genetic Testing - Models for the Developing World30. Angus Clarke: Ethical Issues Arising in Medical Genetics in Developing Countries31. Robert George Elles: Genetic and Genomics Services in Emerging Economies of the Developing WorldPart II: Genomics in Medicine and Health-RegionalAfrica32. Rym Kefi: Anthropology and Population Heterogeneity in North Africa33. Himla Soodyall and Carina M. Schlebusch: The Genetic Landscape of Sub-Saharan African Populations34. Romdhane Lilia and Abdelhak Sonia: Genetic Disorders in North African Populations35. Neziha Gouider-Khouja and Ibtihel Rebai: Genetic Neurological Diseases in Tunisia36. Ambroise Wonkam and Amanda Krause: Hemoglobinopathies in Africa37. Ambroise Wonkam: The Burden of Birth Defects and Genetic Disease in Sub-Saharan Africa38. Peter Beighton: Genetic Epidemiology of South Atlantic Oceanic Islands39. Peter Beighton: Genetic Disorders in Minority Groups in South Africa40. Peter Beighton and Sean Sellars: Hereditary Deafness in Southern Africa41. Peter Beighton: Heritable Disorders of the Skeleton in South Africa42. Peter Beighton: Heritable Disorders of Connective Tissue in South Africa43. Erika de Wit, Marlo Muller, and Eileen Hoal: Genetic Perspectives of Tuberculosis in Southern Africa44. Yonglan Zheng, Toshio F. Yoshimatsu, and Olufunmilayo I. Olopade: Familial Cancer Syndromes in Africa45. Jacquie Greenberg, Jennifer Kromberg, Kelly Loggenberg, and Tina-Mari. Wessels: Genetic Counseling in South Africa46. Michael Urban and Lut Geerts: Prenatal Diagnostic Services and Prevention of Birth Defects in South Africa47. Claire Penn and Jennifer Watermeyer: Sociocultural Perspectives of Inherited Diseases in Southern Africa48. Jennifer G.R. Kromberg and Trefor Jenkins: Ethical, Legal, and SocioCultural Issues and Genetic Services in Southern Africa49. Billie-Jo Hardy, Beatrice Seguin, Raj Ramesar, Peter A. Singer and Abdallah S. Daar: The Genomic Research and Health Applications in South AfricaArab and Middle East50. Ghazi Omar Tadmouri and Mahmoud Taleb Al Ali: Hereditary Disorders in Arabs51. Ghazi O. Tadmouri, Pratibha Nair, Tasneem Obeid, and Hanan Hamamy: Community Health Implications of Consanguinity in Arab Populations52. Lihadh Al-Gazali and Hanan Hamamy: Clinical Dysmorphology in the Arab World53. Shaikha Salim Al-Arrayed: The Population Genetics and Hereditary Diseases of Bahrain54. Anna Rajab and Michael A.Patton: Genetic Diseases in the Sultanate of Oman55. Issam I. Khneisser, Salim. M. Adib, and Andre Megarbane: Genetic Disorders in Lebanon: Challenges and Opportunities56. Bassam Abu-Libdeh, Peter D. Turnpenny, and Ahmed Teebi: Genetic Disease in Palestine and Palestinians57. Mourad Mokni, Cherine Charfeddine, and Sonia Abdelhak: Genetic Skin Diseases in the Arab World58. Nisrine Bissar-Tadmouri, Mohamad Al-Homssi, and Pratiba Nair: Hereditary Diseases of the Nervous System in Arabs59. Serdar Coskun, Wafa Qubbaj, and Aida I. Al-Aqeel: Preimplantation Genetic Diagnosis in Saudi ArabiaAsia-Pacific60. Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar: Genomics for Universal Healthcare in Thailand61. Carmencita D. Padilla and Bradford L. Therrell: Screening Newborns in the Asia-Pacific Region62. Meow Keong Thong: Clinical Dysmorphology and Birth Defects Registry in the Asia-Pacific Region63. Chanane Wanapirak, Jintana Pattanapongthorn, Pranee Winichagoon, and Suthat Fucharoen: Prevention and Control of Thalassemia in Thailand64. Pornswan Wasant: Inherited Metabolic Disorders in Thailand and the Asia-Pacific65. Pornswan Wasant: Genetic Skeletal Dysplasias in Thailand66. Carmencita Padilla, Eva Maria Cutiongco-de la Paz, and Catherine Lynn Silao: Medical Genetic Services in the PhilippinesChinese Subcontinent67. Manshu Song, Youxin Wang, Lijuan Wu, Yun Wang, and Wei Wang: Community and Public Health Genetics in China68. Peng-Gao Li, Yan He and Wei Wang: Genetic Epidemiology in China69. Hong-Min Yun, Manshu Song, and Wei Wang: Traditional Chinese Medicine in the Area of Genomics70. Ling Zhang Ying Dai, and Wei Wang: Inherited Factors in Cardiovascular Disease in China71. Fen Liu and Wei Wang: Familial and Genetic Cancer in China72. Ming Ta Michael Lee, Chien-Hsiun Chen, and Yuan-Tsong Chen: Genomic Medicine in Taiwan: Research and DevelopmentsIndian Subcontinent73. Dhavendra Kumar: The Indian Subcontinent and its People74. Ganesh Prasad Arunkumar, Varatharajan Santhakumari Arun, Adhikarla Syama, Valampuri John Mary Selvam Kavitha, and Ramasamy M. Pitchappan: Genomic Perspectives of Peopling and Languages of the Indian Subcontinent75. Narinder K. Mehra and Gurvinder Kaur: Genomic Diversity of HLA in the Indian Subcontinent76. Billie-Jo Hardy, Beatrice Seguin, Peter A. Singer, Mitali Mukerji, Samir K. Brahmachari and Abdallah S. Daar: Genomic Applications in Medicine and Health in India77. Ishwar C. Verma and Dhavendra Kumar: Epidemiology of Genetic Diseases in the Indian Subcontinent78. Ratna D. Puri and Ishwar C. Verma: Genetic Services in India: A Model for Developing Countries79. Meenakshi Bhatt: The Practice of Genetic Counseling in India80. Rafat Hussain: Social and Cultural Aspects of Customary Consanguineous Marriages in South Asia81. Vajira H.W. Dissanayake: Medical Genetics and Genomics in Sri Lanka82. Amrendra Kumar Gupta, Balaram Ghosh, and Anurag Agrawal: Inherited Factors in Obstructive Lung Diseases in India83. Bal N. Apte: Inherited Metabolic Disease in India84. Deepthi C. de Silva: Genetic Variation and Genetic Epidemiology of Sri Lanka85. Dhavendra Kumar: Familial Cancer and Cancer Genetics in the Indian Subcontinent86. Govindasamy Kumaramanickavel: Inherited Disorders of the Eye in the Indian Subcontinent87. Radha Venkatesan, Kanthimathi Sekar and Viswanathan Mohan: Type 2 Diabetes Mellitus in India88. Mohammed Faruq, Uma Mittal, Achal K. Srivastava, and Mitali Mukerji: Hereditary Spinocerebellar Ataxias in India89. Shubha Phadke: Malformation Syndromes in India90. John Old: Thalassemias and Abnormal Hemoglobins of the Indian Subcontinent91. Reena Das: The Management of Inherited Blood Diseases in the Indian Subcontinent92. Prochi F. Madon: Conventional and Molecular Cytogenetics in India93. Jharna Ray: Genetic Studies of Parkinson's Disease in India94. Meera Vasani: The Genetic Basis of Alcoholism in India95. G.K. Chetan, K.R. Manjunatha, Sam Balu, H.N. Venkatesh, and S.C. Grimaji: The Genetics of Autism in India96. Mariakuttikan Jayalakshmi, Narayanan Kalyanaraman, and Ramasamy Pitchappan: The Genetics of Leprosy in India97. Neerja Gupta and Madhulika Kabra: The Current Status of Medical Genetics in India98. Swati Naik, Arvind Rup Singh, and Jai Rup Singh: The Indian Landscape of Human/Medical Genetics Research and ServiceLatin America and the Caribbean99. Gerardo Jiminez-S nchez, Julio Frenk, and Guillermo Sobercn: Design and Implementation of a Platform for Genomic Medicine in Mexico100. Ricardo M. Cerda-Flores and Augusto Rojas-Martinez: Anthropological and Medical Implications of Genetic Admixture in the Mexican Mestizo Population101. Cesar Paz-y-Mio: Medical and Human Genetics in Ecuador102. Sergio D.J. Pena: The Brazilian Ancestrome103. Dafne Dain Gandelman Horovitz, Antonia Paula Marques-de-Faria, and Victor Evangelista de Faria Ferraz: The Practice of Medical Genetics in Brazil104. Lavinia Schuller-Faccini and Roberto Giugliani: Population Medical Genetics in Brazil105. Victor B. Penchaszadeh: Medical Genetic Services in Latin America: Focus in Argentina106. Luis Velazquez-Perez, Jose Miguel Laffita-Mesa, and Roberto Rodr!guez-Labrada: Hereditary Ataxias in Cuba107. Roberto Giugliani, Guilherme Baldo, and Ursula Matte: Latin American School of Human and Medical Genetics and Latin American Network of Human Genetics: promoting education, interaction and networking across Latin AmericaRussia, Central Asia, and Europe108. I.A. Kutuev, B.B. Yunusbayev, and E.K. Khusnutdinova: Genetic Legacy of Populations in Eurasia109. Sardana A. Fedorova, Elza K. Khusnutdinova, and Richard Villems: MtDNA and Y-chromosomal Variation in Populations of Sakha (Yakutia)110. E.K. Ginter and R.A. Zinchenko: Epidemiology of Hereditary Diseases in the European Sector of Russia111. Nadezda R. Maksimova and Anna N. Nogovitsina: Hereditary Diseases among the Yakuts112. Ludmila P. Nazarenko and V.P. Puzyrev: Hereditary Diseases in Siberian Populations113. Irina M. Khidiyatova, Irina R. Gilyazova, Vita L. Akhmetova and Elza K. Khusnutdinova: Hereditary Diseases in the Volga-Ural Region of Russia114. D. Gaysina, A. Zainullina, and E. Khusnutdinova: Inherited Neuropsychiatric Disorders in Russia115. Bela Melegh: Genetic and Genomic Perspectives of Medical and Health Education in Hungary116. A. Kazantseva, G. Faskhutdinova, and E. Khusnutdinova: Human and Medical Genetics in Hungary117. A. Kazantseva, G. Faskhutdinova, and E. Khusnutdinova: The Genetics of Alcohol Dependence in Russia118. S.I. Kozlova and E.K. Ginter: Medical Genetics Teaching and Training in Russia119. V.L. Izhevskaya and V.I. Ivanov: Ethical and Legal Aspects of Medical Genetics in Russia120. S.K. Kononova, S.A. Fedorova, and E. Khusnutdinova: Bioethical Aspects of Genetics and Genomics in Yakut (Siberia)121. Anupam Chakrapani and Maureen Cleary: Inherited Metabolic Diseases among Migrant Ethnic Populations in the United Kingdom122. Alison Shaw and Jane Hurst: Views of Inherited illness among British Pakistani Users of Genetic Services123. Santi Rozario and Sophie Gilliat-Ray: Social, Cultural, and Religious Issues Related to Genetic Diseases among the Bangladeshis in the UK