Glial Cell Development: Basic Principles and Clinical Relevance

Hardcover | August 1, 2001

EditorKristjan Jessen, William Richardson

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This is a new edition in the Cellular and Molecular Neurobiology series. The vast majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, andpromote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheathe around axons and provide metabolic and structural support for neurones. Glial cells also have a major influence on the local response to injury of the central nerve tract and the peripheralnervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive, state-of-the-art overview of research into the development, function and malfunction of glial cells. It offers a compelling insight into how basic research throwslight onto diseases and disorders and points the way towards treatments. Teams of internationally renowned experts, all active in research, have contributed chapters.

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This is a new edition in the Cellular and Molecular Neurobiology series. The vast majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, andpromote and guide axonal growth. In the mature...

Professor Kristjan Jessen Department of Anatomy and Developmental Biology University College London Gower Street London WC1E 6BT Tel: 0207 679 2000 Fax: 0207 679 7349 E-mail: k.jessen@ucl.ac.uk Professor William Richardson The Wolfson Institute for Medical Research University College London Gower Street London WC1E 6BT Tel: 020...
Format:HardcoverPublished:August 1, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198524781

ISBN - 13:9780198524786

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Table of Contents

1. Mirsky and Jessen: Embryonic and early postnatal development of Schwann cells2. Richardson: Origins and early development of oligodendrocytes3. Goldman: Developmental origins of astrocytes4. Perry: Microglia in the developing and mature central nervous system5. Magistretti, Pellerin and Therianos: The metabolic functions of glial cells during development and in maturity6. Gallo, Ghiani and Yuan: The role of ion channels and transmitter receptors on glial cells7. Ellisman, Deerinck and Bennett: Structure and formation of the node of Ranvier8. Colman, Pedraza and Yoshida: Myelin sheath structure, function and evolution9. Nave: Myelin-specific genes and their mutations in the mouse10. Hudson: Control of gene expression by oligodendrocytes11. Topilko and Meijer: Transcription factors that control Schwann cell development and myelination12. Granderath and Klambt: Genetic analysis of gliogenesis in Drosophila13. Fitch and Silver: Functions of astrocytes14 Glial influences on axonal growth. Filbin, Qiu and Cai: 15. Scherer and Salzer: Axon-Schwann cell interactions during peripheral nerve degeneration and regeneration16. Wrabetz, Feltri, Hanemann and Muller: The molecular genetics of hereditary demyelinating neuropathies17. Ratner and Daston: Genetic and cellular mechanisms of Schwann cell tumour formation: neurofibromatosis type 1 and neurofibromatosis type 218. Lucchinetti and Lassmann: The neuropathology of Multiple Sclerosis19. Blakemore, Franklin and Noble: Restoring CNS myelin by glial cell transplantation20. Brustle and Dubois-Dalcq: Stem cells and their gliogenic potential21. Nister, Uhrbom, Hesselager and Westermark: Glial tumours of the CNS