GPCRs: From Deorphanization to Lead Structure Identification by H. BourneGPCRs: From Deorphanization to Lead Structure Identification by H. Bourne

GPCRs: From Deorphanization to Lead Structure Identification

EditorH. Bourne, Richard Horuk, J. Kuhnke

Paperback | November 30, 2010

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This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.
Title:GPCRs: From Deorphanization to Lead Structure IdentificationFormat:PaperbackDimensions:288 pages, 8.27 × 5.12 × 0 inPublished:November 30, 2010Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642080316

ISBN - 13:9783642080319

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Table of Contents

G Proteins and GPCR: From the Beginning.- Modelling GPCRs.- Privileged Structures in GPCRs.- Designing Compound Libraries Targeting GPCRs.- Virus-encoded G Protein Coupled Receptors: Constitutively Active (dys) Regulators of Cell Function and their Potential as Drug Target.- Modulation of GPCR Conformations by Ligands, G Proteins and Arrestins.- The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling.- Orphan Seven Transmembrane Receptor (7TMR) Screening.- High Content Screening to Monitor G Protein-Coupled Receptor Internalization.- High Throughput Lead Finding and Optimisation for GPCR Targets.