Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 1 by Pabulo  H. RampelottoGrand Celebration: 10th Anniversary of the Human Genome Project: Volume 1 by Pabulo  H. Rampelotto

Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 1

Guest editorPabulo H. Rampelotto

Hardcover | February 5, 2016

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In 1990, scientists began working together on one of the largest biological research projects
ever proposed. The project proposed to sequence the three billion nucleotides in the human
genome. The Human Genome Project took 13 years and was completed in April 2003, at a
cost of approximately three billion dollars. It was a major scientific achievement that forever
changed the understanding of our own nature. The sequencing of the human genome was in
many ways a triumph for technology as much as it was for science. From the Human Genome
Project, powerful technologies have been developed (e.g., microarrays and next generation
sequencing) and new branches of science have emerged (e.g., functional genomics and
pharmacogenomics), paving new ways for advancing genomic research and medical
applications of genomics in the 21st century. The investigations have provided new tests and
drug targets, as well as insights into the basis of human development and diagnosis/treatment
of cancer and several mysterious humans diseases. This genomic revolution is prompting a
new era in medicine, which brings both challenges and opportunities. Parallel to the
promising advances over the last decade, the study of the human genome has also revealed
how complicated human biology is, and how much remains to be understood. The legacy of
the understanding of our genome has just begun. To celebrate the 10th anniversary of the
essential completion of the Human Genome Project, in April 2013 Genes launched this
Special Issue, which highlights the recent scientific breakthroughs in human genomics, with a
collection of papers written by authors who are leading experts in the field.


John Burn, James R. Lupski,
Karen E. Nelson and Pabulo H. Rampelotto
Guest Editors

Title:Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 1Format:HardcoverProduct dimensions:276 pages, 9.61 × 6.69 × 0.88 inShipping dimensions:9.61 × 6.69 × 0.88 inPublished:February 5, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421243

ISBN - 13:9783038421245

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Table of Contents

Revisiting Respect for Persons in Genomic ResearchGenetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human GenomeProject SuccessThe Past, Present, and Future of Human Centromere GenomicsLessons and Implications from Genome-Wide Association Studies (GWAS) Findings ofBlood Cell PhenotypesThe Genomic Signature of Breast Cancer PreventionLessons from Genome-Wide Search for Disease-Related Genes with Special Reference toHLA-Disease AssociationsPhenotype-Based Genetic Association Studies (PGAS)-Towards Understanding theContribution of Common Genetic Variants to Schizophrenia SubphenotypesMechanisms of Base Substitution Mutagenesis in Cancer GenomesThe Molecular Basis of Retinal Dystrophies in PakistanAssociation Claims in the Sequencing EraGenetic Profiling for Risk Reduction in Human Cardiovascular DiseaseIlluminating the Transcriptome through the GenomeArchitecture of Inherited Susceptibility to Colorectal Cancer: A Voyage of DiscoveryReading and Language Disorders: The Importance of Both Quantity and Quality