Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 2 by Pabulo H. RampelottoGrand Celebration: 10th Anniversary of the Human Genome Project: Volume 2 by Pabulo H. Rampelotto

Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 2

Guest editorPabulo H. Rampelotto

Hardcover | February 5, 2016

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In 1990, scientists began working together on one of the largest biological research projects
ever proposed. The project proposed to sequence the three billion nucleotides in the human
genome. The Human Genome Project took 13 years and was completed in April 2003, at a
cost of approximately three billion dollars. It was a major scientific achievement that forever
changed the understanding of our own nature. The sequencing of the human genome was in
many ways a triumph for technology as much as it was for science. From the Human Genome
Project, powerful technologies have been developed (e.g., microarrays and next generation
sequencing) and new branches of science have emerged (e.g., functional genomics and
pharmacogenomics), paving new ways for advancing genomic research and medical
applications of genomics in the 21st century. The investigations have provided new tests and
drug targets, as well as insights into the basis of human development and diagnosis/treatment
of cancer and several mysterious humans diseases. This genomic revolution is prompting a
new era in medicine, which brings both challenges and opportunities. Parallel to the
promising advances over the last decade, the study of the human genome has also revealed
how complicated human biology is, and how much remains to be understood. The legacy of
the understanding of our genome has just begun. To celebrate the 10th anniversary of the
essential completion of the Human Genome Project, in April 2013 Genes launched this
Special Issue, which highlights the recent scientific breakthroughs in human genomics, with a
collection of papers written by authors who are leading experts in the field.


John Burn, James R. Lupski,
Karen E. Nelson and Pabulo H. Rampelotto
Guest Editors

Title:Grand Celebration: 10th Anniversary of the Human Genome Project: Volume 2Format:HardcoverProduct dimensions:268 pages, 9.61 × 6.69 × 0.88 inShipping dimensions:9.61 × 6.69 × 0.88 inPublished:February 5, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421251

ISBN - 13:9783038421252

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Table of Contents

The Epigenome View: An Effort towards Non-Invasive Prenatal DiagnosisPolygenic Scores Predict Alcohol Problems in an Independent Sample and Show Moderationby the EnvironmentEpigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylationin Buccal CellsCharacterization of the Genomic Architecture and Mutational Spectrum of a Small CellProstate CarcinomaThe Little Fly that Could: Wizardry and Artistry of Drosophila GenomicsGenome-Wide Analysis of Alpharetroviral Integration in Human HematopoieticStem/Progenitor CellsPharmacogenomics: Current State-of-the-ArtChanging Histopathological Diagnostics by Genome-Based Tumor ClassificationGWAS to Sequencing: Divergence in Study Design and AnalysisImprinted Genes and the Environment: Links to the Toxic Metals Arsenic, Cadmium and LeadThe Impact of the Human Genome Project on Complex DiseaseFrom Genotype to Functional Phenotype: Unraveling the Metabolomic Features ofColorectal CancerAn Efficient Estimator of the Mutation Parameter and Analysis of Polymorphism from the1000 Genomes ProjectThe Challenges of Genome Analysis in the Health Care Setting