Growth Factors and Receptors: A Practical Approach

Paperback | July 1, 1998

EditorIan A. McKay, Kenneth D. Brown

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Growth Factors and Receptors: A Practical Approach provides comprehensive protocols for studies of growth factors and their interactions with receptors. It covers a wide range from simple analytical techniques to sophisticated in vivo applications including: RT-PCR and immunocytochemistry fordetection of growth factors and receptors; production and purification of recombinant growth factors and receptors; labelling of growth factors for binding studies; in vivo mutagenesis; the yeast two-hybrid assay of proteinprotein interactions; phage display of factors; application of factors towound-healing processes using the gene gun; treatment of cancers with factor/toxin chimeras; and analysis of important factor domains using chimeric proteins. This book updates and extends the current literature and describes important novel approaches to the study of growth factors and theirreceptors, including the use of RNA aptamers as receptor antagonists, and the development of receptor superantagonists. It will be of tremendous value to both researchers and teachers, and, through an appendix that lists a large number of growth factors and receptors, will serve as a handy referencetext.

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Growth Factors and Receptors: A Practical Approach provides comprehensive protocols for studies of growth factors and their interactions with receptors. It covers a wide range from simple analytical techniques to sophisticated in vivo applications including: RT-PCR and immunocytochemistry fordetection of growth factors and receptors; p...

Dr Ian A. McKay Senior Lecturer in Dermatology Centre for Cutaneous Research 2 Newark Street London E1 2AT Tel: 0171 295 7160 Fax: 0171 295 7171 Email: I.A.McKay@mds.qmw.ac.uk Dr Kenneth D. Brown Institute of Animal Physiology The Babraham Institute Babraham Hall Babraham, Cambridge CB2 4AT Tel: 01223 833312 Fax: 01223 833511 Email:...

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Format:PaperbackPublished:July 1, 1998Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019963646X

ISBN - 13:9780199636464

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Table of Contents

1. Engineered growth factors and receptors, and their applications2. Engineering of novel neurotrophins3. Designing new agonists.antagonists of growth factor receptors - the rational design of a super-antagonist of the IL-6 receptor4. A Chimeric approach for studying receptor-binding domains in EGF-like molecules5. Structure-activity relationships of chemokines6. Generation and selection of RNA ligands that inhibit interaction of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to its receptor7. Immunolocalisation and RT-PCR for detection and quantification of growth factor and gene expression8. Defining growth factor function through tissue-specific expression of dominant-negative receptor mutants9. Growth factor-toxin chimeras and their applications10. Gene therapy applications of growth factorsAppendix 1Appendix 2Appendix 3