Guidebook to Protein Toxins and Their Use in Cell Biology

Paperback | May 1, 1997

EditorRino Rappuoli, Cesare Montecucco

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Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid providedby ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and proteinsynthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

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Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid providedby ants to bacterial proteins composed of tho...

Rino Rappuoli is at Instituto Richerche Immunobiologiche Siena, Siena. Cesare Montecucco is at Instituto di Patalogia Generale, Universita di Padova.

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Format:PaperbackDimensions:274 pages, 9.69 × 7.44 × 0.71 inPublished:May 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198599544

ISBN - 13:9780198599548

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Table of Contents

1. Membrane permeabilizing toxins2. Toxins affecting signal transduction3. Toxins affecting protein synthesis4. Cytoskeleton-affecting toxins5. Toxins affecting the immune and inflammatory response6. Toxins affecting membrane traffic7. Sodium channel-targeted toxins8. Potassium channel-targeted toxins9. Calcium channel-targeted toxins10. Acetylcholine receptor targeted toxins11. Ryanodine receptor toxins12. Presynaptic toxins13. Glutamate receptor-targeted toxins

Editorial Reviews

The authors have concisely compiled structure, function, and toxicity data for 78 protein toxins in a unique, accessible format that allows cell biologists to learn how protein toxins have aided in the dissection of cellular processes. --Journal of Chemical Education"Both our understanding of the actions of protein toxins and their uses as tools in cell biology have undergone an explosion in recent years. It almost seems that there is now a toxin to disrupt every aspect of cell metabolism. This volume is composed of short (1 to 3 page) summaries on themechanism of action and uses of over 75 different protein toxins. It will be an invaluable reference for biological sciences and medical school libraries. Given the rapid pace of progress in this area, an additional attraction of this work is that updated information will be available on the WorldWide Web."--The Quarterly Review of Biology