This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene expression and cell-cycle control, clearly highlighting its importance. Addressing many aspects of the secretory pathway, the book contains almost two hundred entries, and falls in five sections: protein secretion in E.coli; translocation and maturation of newly synthesized polypeptides in the ER of eukaryotic cells; protein machines and catalyzing ER to golgitransport; membrane traffic in the golgi and to the cell surface, and membrane traffic to the lysosome/vacuole. Providing key references in a clear, informative layout, this book provides a valuable guide to the bewildering and complex array of genes and proteins involved in the cellular secretory pathway. The guidebook will maintain up to date entries - the almost two hundred contributors will update their entries continuously, and these updates will be available via the Internet.