Handbook of Biological Nonlinear Optical Microscopy

Hardcover | June 1, 2008

EditorBarry R. Masters, Peter So

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The Handbook of Biomedical Nonlinear Optical Microscopies provides comprehensive treatment of the theories, techniques, and biomedical applications of nonlinear optics and microscopy for cell biologists, life scientists, biomedical engineers, and clinicians. The chapters are separated intobasic and advanced sections, and provide both textual and graphical illustrations of all key concepts. The more basic sections are aimed at life scientists without advanced training in physics and mathematics, and tutorials are provided for the more challenging sections. The first part of the Handbook introduces the historical context of nonlinear microscopy. The second part presents the nonlinear optical theory of two- and multiphoton excited fluorescence (TPE, MPE) spectroscopy, second and third harmonic generation (SHG, THG) spectroscopy, and coherentanti-Stokes Raman spectroscopy (CARS). The third part introduces modern microscopic and spectroscopic instrumentation and techniques that are based on nonlinear optics. The fourth part provides key applications of nonlinear microscopy to the biomedical area: neurobiology, immunology, tumor biology,developmental biology, dermatology, and cellular metabolism. There are also chapters on nonlinear molecular probes, cellular damage, and nanoprocessing.

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The Handbook of Biomedical Nonlinear Optical Microscopies provides comprehensive treatment of the theories, techniques, and biomedical applications of nonlinear optics and microscopy for cell biologists, life scientists, biomedical engineers, and clinicians. The chapters are separated intobasic and advanced sections, and provide both t...

Barry Masters is a Visiting Scientist in the Biological Engineering Division at Massachusetts Institute of Technology. Peter So is a Professor of Mechanical and Biological Engineering at Massachusetts Institute of Technology.

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Format:HardcoverDimensions:784 pages, 10 × 7 × 0.98 inPublished:June 1, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195162609

ISBN - 13:9780195162608

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Table of Contents

Part I. Historical Development of Nonlinear Optical Spectroscopy and MicroscopyIntroduction to Part I: Historical Development of Nonlinear Optical Microscopy and SpectroscopyChapter 1. The Genesis of Nonlinear Optical Microscopies and their Impact on Modern Developments.Chapter 2. The Scientific Life of Maria Goppert-MayerChapter 3. The History of Perturbation Theory from Astronomy to Quantum MechanicsChapter 4. English Translations of and Translator's Notes on Maria Goppert-Mayer's Theory of Two-Quantum ProcessesPart II. Nonlinear Optical SpectroscopyIntroduction to Part II: Nonlinear Optical SpectroscopyChapter 5. Classical and Quantum Theory of One-Photon and Multiphoton Fluorescence SpectroscopyChapter 6. Second- and Higher-Order Harmonic GenerationChapter 7. Theory of Spontaneous and Coherent Raman ScatteringPart III. Nonlinear Optical Instruments for Microscopic Imaging and AnalysisIntroduction to Part III: Nonlinear Optical Instruments for Microscopic Imaging and Analysis: Review and ForecastChapter 8. Laser Sources for Non-Linear MicroscopyChapter 9. Ultrashort Optical Pulse Delivery for Nonlinear Optical MicroscopyChapter 10. An Optical Design Primer for Nonlinear Optical MicroscopyChapter 11. Image Formation in Multiphoton Fluorescence MicroscopyChapter 12. Signal Detection and Processing in Nonlinear Optical MicroscopesChapter 13. Multiphoton Excitation of Fluorescent ProbesChapter 14. Multiphoton-Induced Cell DamageChapter 15. Applications of Second-Harmonic Generation MicroscopyChapter 16. Second-Harmonic Generation Imaging Microscopy of Structural ProteinChapter 17. Coherent Anti-Stokes Raman Scattering (CARS) Microscopy: Instrumentation and ApplicationsChapter 18. High-speed Imaging Using Multiphoton ExcitationChapter 19. Nonlinear Multi-Spectral Optical Imaging Microscopy: Concepts, Instrumentation, and ApplicationsChapter 20. Multiphoton Polarization MicroscopyChapter 21. Lifetime-Resolved Imaging in Nonlinear MicroscopyChapter 22. Forster Resonance Energy Transfer (FRET)Chapter 23. Two-Photon Forster Resonance Energy Transfer (FRET) MicroscopyChapter 24. Diffraction Unlimited Far-Field Fluorescence MicroscopyChapter 25. Two-Photon Fluorescence Correlation SpectroscopyChapter 26. Photobleaching and Recovery with Nonlinear MicroscopyChapter 27. Femtosecond Laser NanoprocessingPart IV. Biomedical Applications of Nonlinear Optical MicroscopyIntroduction to Part IV: Biomedical Applications of Nonlinear Optical MicroscopyChapter 28. Pioneering Applications Of Two-Photon Microscopy To Mammalian Neurophysiology: Seven Case StudiesChapter 29. Applications of Non-Linear Intravital Microscopy in Tumor BiologyChapter 30. Immunology Based on Nonlinear Optical MicroscopyChapter 31. Multiphoton Imaging in Animal DevelopmentChapter 32. Nonlinear Microscopy Applied to DermatologyChapter 33. Cellular Metabolism Monitored by NAD(P)H Imaging with Two-Photon Excitation Microscopy