Handbook Of Pharmacogenomics And Stratified Medicine

Paperback | October 30, 2017

bySandosh Padmanabhan

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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

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From the Publisher

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in v...

Dr Sandosh Padmanabhan is a Reader and Honorary Consultant Physician at the Institute of Cardiovascular and Medical Sciences, University of Glasgow. His research spans the genetics of cardiovascular traits, pharmacogenomics and stratified medicines and hypertension epidemiology.
Format:PaperbackDimensions:1118 pages, 8.75 × 6.35 × 0.68 inPublished:October 30, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128100524

ISBN - 13:9780128100523

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Table of Contents

Handbook of Pharmacogenomics and Stratified Medicineincludes 46 chapters within the following sections:

I. Introduction II. Basic genetics III. Experimental and discovery platforms IV. Statistics, bioinformatics, and databases V. Clinical trials VI. Fundamental pharmacogenomics VII. Applications in therapeutics VIII. Implementation and regulatory IX. Global perspective