Handbook of Psychopharmacology: Volume 10: Neoroleptics and Schizophrenia by Leslie IversenHandbook of Psychopharmacology: Volume 10: Neoroleptics and Schizophrenia by Leslie Iversen

Handbook of Psychopharmacology: Volume 10: Neoroleptics and Schizophrenia

EditorLeslie Iversen

Paperback | October 12, 2011

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Title:Handbook of Psychopharmacology: Volume 10: Neoroleptics and SchizophreniaFormat:PaperbackPublished:October 12, 2011Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461340446

ISBN - 13:9781461340447

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Table of Contents

1 Structure-Activity Relationships of the Butyrophenones and Diphenylbutylpiperidines.- 1. Introduction.- 2. Structure-Activity Relationships.- 2.1. Butyrophenones.- 2.2. Diphenylbutylpiperidines.- 3. Pharmacology.- 3.1. Potency and Duration of Action.- 3.2. Oral Effectiveness.- 3.3. Antipsychotic Activity.- 3.4. Side-Effect Liability.- 4. Conclusion.- 5. References.- 2 Biochemical Actions of Neuroleptic Drugs: Focus on the Dopamine Receptor.- 1. Introduction.- 2. Early Biochemical Studies.- 3. Dopamine Metabolism and Neuroleptics.- 4. The Dopamine-Sensitive Adenylate Cyclase.- 5. Labeling the Dopamine Receptor.- 5.1. Evidence for a Two-State Model of the Dopamine Receptor.- 5.2. LSD as a Mixed Agonist-Antagonist at Dopamine Receptors.- 5.3. Dopamine-Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs.- 5.4. Dopamine-Receptor Binding Increases after Destruction of Dopamine Innervation: Correlation with Behavioral Supersensitivity.- 5.5. Dopamine-Receptor Binding after Chronic Drug Treatment.- 5.6. A Radioreceptor Assay to Measure Blood Neuroleptic Levels.- 5.7. Labeling Dopamine Receptors in Brain and Pituitary with [3H]Spiroperidol.- 6. References.- 3 Behavioral Actions of Neuroleptics.- 1. Introduction.- 2. Effect on Feeding and Drinking.- 2.1. Feeding in Normal Animals.- 2.2. Recovery from Lateral Hypothalamic Syndrome.- 3. Locomotor Activity and Catalepsy.- 4. Antiamphetamine Action.- 4.1. Stereotypy.- 4.2. Mouse Jumping.- 4.3. Agitation and Oxygen Consumption.- 4.4. Circling Behavior.- 5. Avoidance Behavior.- 6. Brain Self-Stimulation.- 7. Aggression.- 7.1. Apomorphine-Induced Aggression.- 7.2. Morphine-Withdrawal Aggression.- 7.3. Isolation-Induced Aggression.- 7.4. Pain-Induced Aggression.- 8. Narcotic-Withdrawal Syndrome.- 9. Conclusions.- 10. References.- 4 Neuroleptics: Clinical Use in Psychiatry.- 1. Introduction.- 2. The Methodology of Drug Studies.- 3. Efficacy of Antipsychotic Drugs.- 3.1. Comparative Effects.- 3.2. High-Dose Phenothiazine Treatment.- 3.3. Blood Levels and Therapeutic Response.- 4. Maintenance Treatment with Antipsychotic Medication.- 4.1. Drug Holidays.- 5. Cost of Medication and Dispensing.- 6. Antipsychotic Drugs and Somatic Therapies.- 7. Drug Combinations.- 8. Drug, Psychological, and Social Treatments.- 9. New Antipsychotic Drugs.- 10. References.- 5 Tardive Dyskinesia and Related Neurologic Disorders.- 1. Historical Background.- 2. Clinical Findings.- 2.1. Classification.- 2.2. Description.- 3. Predisposing Factors.- 3.1. Age.- 3.2. Sex.- 3.3. Diagnosis.- 4. Drug Effects.- 4.1. Dosage and Total Intake.- 4.2. Types of Drugs.- 4.3. Duration of Treatment.- 4.4. Current Drug Status.- 4.5. Outcome.- 5. Severity and Combinations of Symptoms.- 6. Disability and Complications.- 7. Differential Diagnosis.- 8. Pathophysiology.- 9. Neuropharmacology.- 9.1. Huntington's Disease as a Model for Tardive Dyskinesia.- 9.2. Levodopa in Parkinsonism as a Model for Tardive Dyskinesia.- 9.3. Other Models for Tardive Dyskinesia.- 9.4. Animal Studies.- Therapy.- 11. Concluding Remarks.- 12. References.- 6 Reserpine: Basic and Clinical Pharmacology.- 1. Introduction.- 2. Source, History, and Analogs.- 3. Distribution and Metabolism.- 4. Pharmacological Effects in Laboratory Animals.- 5. Clinical Pharmacology.- 6. Biochemical Mechanism of Action.- 7. Interaction of Reserpine with Other Centrally Acting Drugs.- 8. The Reserpine Receptor.- 9. References.- 7 Neurotransmitter Theories of Schizophrenia.- 1. Introduction.- 2. Survey of Neurotransmitter Theories.- 2.1. Acetylcholine.- 2.2. Noradrenaline.- 2.3. Serotonin.- 2.4. Gamma-Aminobutyric Acid.- 2.5. Dopamine.- 3. General Principles Underlying Neurotransmitter Theories in Psychiatry.- 3.1. Stereotypy Model.- 3.2. Chorea Model.- 4. Attention in Schizophrenia and Its Pharmacology.- 5. References.