Handbook of the Biology of Aging

Other | April 1, 2011

byMasoro, Edward J., Edward J. Masoro

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The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses.

The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship.

The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging.

The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.

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From the Publisher

The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, wi...

Format:OtherDimensions:680 pages, 1 × 1 × 1 inPublished:April 1, 2011Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080491405

ISBN - 13:9780080491400

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Table of Contents

HANDBOOK OF THE BIOLOGY OF AGING, 6e

Edited by Edward J. Masoro and Steve Austad

Section I: Conceptual and Technical Issues

Chapter 1
Reliability Theory of Aging and Longevity
Leonid A. Gavrilov and Natalia S. Gavrilova

Chapter 2 - Are Age-Associated Diseases an Integral Part of Aging?
Edward J. Masoro

Chapter 3 - Dietary Restriction, Hormesis and Small Molecule Mimetics
David A. Sinclair and Konrad T. Howitz

Chapter 4 - Hematopoietic Stem Cells, Aging, and Cancer
Deborah Bell and Gary Van Zant

Chapter 5 - Mitochondria: A Critical Role in Aging
Tamara Golden, Karl Morten, Felicity Johnson, Enrique Samper, and Simon Melov

Chapter 6 - P53 and Mouse Aging Models
Cathy Gatza, George Hinkal, Lynette Moore, Melissa Dumble, and Lawrence A. Donehower

Chapter 7 - Complex Genetic Architecture of Drosophila Longevity
Trudy Mackay, Natalia V. Roshina, Jeff W. Leips, and Elena G. Pasyukova

Chapter 8 - Evolutionary Biology of Aging: Future Directions
Daniel Promislow, Ken Fedorka, and Joep Burger

Chapter 9 - Senescence in Wild Populations of Mammals and Birds
Anja Brunet-Rossini and Steven N. Austad

Chapter 10 - Biodemography of Aging and Age-Specific Mortality in Drosophila melanogaster
James Curtsinger, Natalia S. Gavrilova, and Leonid A. Gavrilov

Chapter 11 - Microarray Analysis of Gene Expression Changes in Aging
F. Noel Hudson, Matt Kaeberlein, Nancy Linford, David Pritchard, Richard Beyer, and Peter S. Rabinovitch

Chapter 12 - Computer Modeling in the Study of Aging
Thomas Kirkwood, Richard Boys, Colin Gillespie, Carole Procter, Daryl Shanley, and Darren Wilkenson

Section II: Non-Mammalian Models

Chapter 13 - Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans
Thomas E. Johnson, Samuel T. Henderson, Shane Rea

Chapter 14 - Genetic Manipulation of Life span in Drosophila. Melanogaster
Daniel Ford and John Tower

Chapter 15 - Juvenile and Steroid Hormones in Drosophila melanogaster Longevity
Meng-Ping Tu, Thomas Flatt,, Marc Tatar

Chapter 16 - A Critical Evaluation of Nonmammalian Models for Aging Research
Steven N. Austad, Andrej Podlutsky

Section III: Mammalian Models

Chapter 17 - Differential Aging Among Skeletal Muscles
Roger J. M. McCarter

Chapter 18 - Aging, Body Fat, and Carbohydrate Metabolism
Marielisa Rincon, Radhika Muzumdar, and Nir Barzilai

Chapter 19 - Growth and Aging: Why do Big Dogs Die young?
Richard Miller and Steven N. Austad

Chapter 20 - Growth Hormone, Insulin-Like Growth Factor-1 and the Biology of Aging
Christy S. Carter and William E. Sonntag

Chapter 21 - Aging of the Female Reproductive System
Phyllis Wise