Hannahs Heirs: The Quest for the Genetic Origins of Alzheimers Disease

Paperback | June 1, 1993

byDaniel A. Pollen

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The internationally acclaimed story of Hannah's Heirs now resumes in this updated paperback edition with the discovery in June, 1995 of Hannah's gene--now known to account for the majority of mutations causing early onset familial Alzheimer's disease--and the equally important identificationof the major genetic risk factor rendering increased susceptibility to the more frequently occurring late-onset Alzheimer's. With these recent discoveries, medical science is now poised to reach for an understanding of the causes of the various forms of Alzheimer's disease which, in turn, willinevitably lead to rational attempts to treat and prevent Alzheimer's. This fascinating medical detective story of modern science's promising assault on "the disease of the century" continues to unfold with suspense and to inform and inspire through the final word. In Hannah's Heirs, neurologist Dr. Dan Pollen himself tells the compelling story of Hannah's family and their monumental contributions to the fight against Alzheimer's. We are there in 1985 when Charles presents Pollen with three decades' worth of family medical records as well as data fromstudies that even Pollen and his associates did not then know existed. We see the selfless acts of Hannah's descendants in their struggle against Alzheimer's: great-grandson Jeff's conviction that after his death his brain be used for all possible research; great-granddaughter Lucy's decision toovercome her dread of flying in order to reach the research center for testing; and Charles's continued research in the face of a disease that might strike him at any moment. Pollen sets this gripping story within the larger context of the efforts to solve the mysteries of Alzheimer's. He presents the foundations of modern genetic research, from Gregor Mendel's classic discovery of genes, to Alois Alzheimer's work on the brains of presenile dementia victims, toWatson and Crick's double helix model for the structure of DNA. He narrates the latter-twentieth-century efforts of scientists to systematically narrow down the causes of Alzheimer's: Carlton Gajdusek's research excluding slow viruses as a cause of Alzheimer's; and the stunning discovery of PeterSt. George-Hyslop's group in Toronto in June, 1995 identifying Hannah's gene and thereby opening a new era in understanding the origins of Alzheimer's disease. At the same time, Pollen offers a penetrating look at the ongoing conflicts involved in scientific research, revealing how intensecompetition for prestige and funding has driven some scientists to hoard precious cell lines. These practices have impeded efforts to discover both the causes and the treatment of Alzheimer's in the shortest possible time. As Hannah's great-grandson Ben has written, "This is a story that had to be told. Aspirations were transcendent, but because it involved people it could not be told without tears." Written by a physician-scientist who has been a central figure in the study of familial Alzheimer's, Hannah's Heirsis an inspiring portrait of the efforts of a courageous family to confront and overcome a "personal biological Holocaust," and an encouraging look at the advances in science that have created the basis for the eventual understanding and treatment of Alzheimer's disease. And for those who have seenthe horrors of Alzheimer's, for all who fear the aging process that will take its toll on everyone, here is an inside look at one of the great medical detective stories of our time.

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From Our Editors

The internationally acclaimed story of Hannah's Heirs now resumes in this updated paperback edition with the discovery in June 1995 of Hannah's gene--now known to account for the majority of mutations causing early onset familial Alzheimer's disease--and the equally important identification of the major genetic risk factor rendering in...

From the Publisher

The internationally acclaimed story of Hannah's Heirs now resumes in this updated paperback edition with the discovery in June, 1995 of Hannah's gene--now known to account for the majority of mutations causing early onset familial Alzheimer's disease--and the equally important identificationof the major genetic risk factor rendering in...

Daniel A. Pollen, M.D., is Professor of Neurology and Physiology at the University of Massachusetts Medical Center.
Format:PaperbackDimensions:336 pages, 9.17 × 6.14 × 0.87 inPublished:June 1, 1993Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195106520

ISBN - 13:9780195106527

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From Our Editors

The internationally acclaimed story of Hannah's Heirs now resumes in this updated paperback edition with the discovery in June 1995 of Hannah's gene--now known to account for the majority of mutations causing early onset familial Alzheimer's disease--and the equally important identification of the major genetic risk factor rendering increased susceptibility to the more frequently occurring late-onset Alzheimer's. 30 illustrations

Editorial Reviews

"Hannah's Heirs wonderfully catches the mood of the hunt for the genes that tragically predispose some rare families to Alzheimer's disease. Through the success of this research, these genetically-haunted families will soon be able to look forward to futures without such bleak endings."--JamesD. Watson, Nobel laureate, co-discoverer of the structure of DNA, and Director of Cold Spring Harbor Laboratory