Harpers Illustrated Biochemistry 30th Edition

Paperback | January 8, 2015

byVictor Rodwell, David Bender, Kathleen M. Botham

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Gain a thorough understanding of the principles ofbiochemistry as they relate to the study of clinical medicine

THE BEST REVIEW FOR THE USMLE!

The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.

All fifty-eight chapters emphasize the medical relevance of biochemistry

  • Full-color presentation includes more than 600 illustrations
  • Each chapter includes a section on BiomedicalImportance and a summary of the topics covered
  • Review questions follow each of the eleven sections
  • Case studies in every chapter emphasize the clinical relevance to biochemistry
  • NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer

    Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.

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From the Publisher

Gain a thorough understanding of the principles ofbiochemistry as they relate to the study of clinical medicineTHE BEST REVIEW FOR THE USMLE!The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Usin...

David A. Bender, PhD, (London, England) Sub-Dean, University College Medical School, Senior Lecturer in Biochemistry, Department of Structural and Molecular Biology and Division of Medical Education, University College London. Kathleen M. Botham, PhD, DSc (London, England), Professor of Biochemistry, Royal Veterinary College, Univer...
Format:PaperbackDimensions:10.7 × 8.5 × 1.3 inPublished:January 8, 2015Publisher:McGraw-Hill EducationLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0071825347

ISBN - 13:9780071825344

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Table of Contents

1Biochemistry & Medicine 1<_o3a_p>

Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD<_o3a_p>

2 Water & pH 6<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

3 Amino Acids & Peptides 15<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

4 Proteins: determination of Primary Structure 25<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

5 Proteins: Higher Orders of Structure 36<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

6 Proteins: Myoglobin & Hemoglobin 51<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

7 Enzymes: Mechanism of Action 60<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

8 Enzymes: Kinetics 73<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

9 Enzymes: Regulation of Activities 87<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

10 Bioinformatics & Computational<_o3a_p>

Biology 97<_o3a_p>

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

11 Bioenergetics: The Role of ATP 113<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

12 Biologic Oxidation 119<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

13 The Respiratory Chain & Oxidative<_o3a_p>

Phosphorylation 126<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

14 Overview of Metabolism & the Provision<_o3a_p>

of Metabolic Fuels 139<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

15 Carbohydrates of Physiological<_o3a_p>

Significance 152<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

16 The Citric Acid Cycle: The Central Pathway<_o3a_p>

of Carbohydrate, Lipid & Amino Acid<_o3a_p>

Metabolism 161<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

17 Glycolysis & the Oxidation of Pyruvate 168<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

18 Metabolism of Glycogen 176<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

19 Gluconeogenesis & the Control of Blood<_o3a_p>

Glucose 185<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

20 The Pentose Phosphate Pathway & Other<_o3a_p>

Pathways of Hexose Metabolism 196<_o3a_p>

David A. Bender, PhD & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

21 Lipids of Physiologic Significance 211<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

22 Oxidation of Fatty Acids: Ketogenesis 223<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

23 Biosynthesis of Fatty<_o3a_p>

Acids & Eicosanoids 232<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

24 Metabolism of Acylglycerols<_o3a_p>

& Sphingolipids 245<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

25 Lipid Transport & Storage 253<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

26 Cholesterol Synthesis, Transport,<_o3a_p>

& Excretion 266<_o3a_p>

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc<_o3a_p>

<_o3a_p> 

27 Biosynthesis of the Nutritionally<_o3a_p>

Nonessential Amino Acids 281<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

28 Catabolism of Proteins & of Amino Acid<_o3a_p>

Nitrogen 287<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

29 Catabolism of the Carbon Skeletons of<_o3a_p>

Amino Acids 297<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

30 Conversion of Amino Acids to Specialized<_o3a_p>

Products 313<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

31 Porphyrins & Bile Pigments 323<_o3a_p>

Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

32 Nucleotides 339<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

33 Metabolism of Purine & Pyrimidine<_o3a_p>

Nucleotides 347<_o3a_p>

Victor W. Rodwell, PhD<_o3a_p>

<_o3a_p> 

34 Nucleic Acid Structure & Function 359<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

35 DNA Organization, Replication,<_o3a_p>

& Repair 370<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

36 RNA Synthesis, Processing,<_o3a_p>

& Modification 394<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

37 Protein Synthesis & the Genetic Code 413<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

38 Regulation of Gene Expression 428<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

39 Molecular Genetics, Recombinant DNA,<_o3a_p>

& Genomic Technology 451<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

40 Membranes: Structure<_o3a_p>

& Function 477<_o3a_p>

Robert K. Murray, MD, PhD & P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

41 The Diversity of the Endocrine<_o3a_p>

System 498<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

42 Hormone Action & Signal<_o3a_p>

Transduction 518<_o3a_p>

P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

43 Nutrition, Digestion,<_o3a_p>

& Absorption 537<_o3a_p>

David A. Bender, PhD & Peter A. Mayes , PhD, DSc<_o3a_p>

44 Micronutrients: Vitamins<_o3a_p>

& Minerals 546<_o3a_p>

David A. Bender, PhD<_o3a_p>

<_o3a_p> 

45 Free Radicals & Antioxidant<_o3a_p>

Nutrients 564<_o3a_p>

David A. Bender, PhD<_o3a_p>

<_o3a_p> 

46 Glycoproteins 569<_o3a_p>

David A. Bender, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

47 Metabolism of Xenobiotics 583<_o3a_p>

David A. Bender, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

48 Clinical Biochemistry 589<_o3a_p>

David A. Bender, PhD, Joe Varghese, MBBS, MD,<_o3a_p>

Molly Jacob, MBBS, MD, PhD, & Robert K.<_o3a_p>

Murray, MD, PhD<_o3a_p>

<_o3a_p> 

49 Intracellular Traffic & Sorting of Proteins 607<_o3a_p>

Kathleen M. Botham , PhD, DSc & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

50 The Extracellular Matrix 627<_o3a_p>

Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

51 Muscle & the Cytoskeleton 647<_o3a_p>

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

52 Plasma Proteins & Immunoglobulins 668<_o3a_p>

Peter J. Kennelly, PhD, Robert K. Murray, MD, PhD, Molly<_o3a_p>

Jacob, MBBS, MD, PhD & Joe Varghese, MBBS, MD<_o3a_p>

<_o3a_p> 

53 Red Blood Cells 689<_o3a_p>

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

54 White Blood Cells 700<_o3a_p>

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD<_o3a_p>

<_o3a_p> 

55 Hemostasis & Thrombosis 711<_o3a_p>

Peter L. Gross, MD, MSc, FRCP(C), Robert K. Murray, MD, PhD,<_o3a_p>

P. Anthony Weil, PhD, & Margaret L. Rand, PhD<_o3a_p>

<_o3a_p> 

56 Cancer: An Overview 722<_o3a_p>

Molly Jacob, MBBS, MD, PhD, Joe Varghese, MBBS, MD,<_o3a_p>

Robert K. Murray, MD, PhD & P. Anthony Weil, PhD<_o3a_p>

<_o3a_p> 

57 Biochemical Case Histories 746<_o3a_p>

David A. Bender, PhD<_o3a_p>

<_o3a_p> 

58 The Biochemistry of Aging 755<_o3a_p>

Peter J. Kennelly, PhD<_o3a_p>

<_o3a_p>