Hematopoiesis: A Developmental Approach

Hardcover | March 15, 2001

EditorLeonard I. Zon

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Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of thebiology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells fortherapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use ofthese cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles ofhematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to beillustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests thatendothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.

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Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of thebiology of blood cells. For instance, hemap...

Leonard I. Zon is at Harvard Medical School.

other books by Leonard I. Zon

Format:HardcoverPublished:March 15, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195124502

ISBN - 13:9780195124507

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Table of Contents

Part I Hematopoietic Progenitors and Stem Cells1. Donald Metcalf: Some General Aspects of Hematopoietic Cell Development2. Koichi Akashi and Irving L. Weissman: Stem Cells and Hematolymphoid Development3. Suzanne J. Pohlmann, William B. Slayton, Gerald J. Spangrude: Stem Cell Populations: Purification and Behavior4. Ihor Lemischka: Regulation of Hematopoietic Stem Cells: Some Conceptual and Practical Considerations5. Gillian May and Tariq Enver: The Lineage Commitment and Self-Renewal of Blood Stem Cells6. Makio Ogawa and Anne G. Livingston: Blast Cell Colony Assays7. Eibhlin Conneally, Donna E. Hogge, and Heather J. Sutherland, and Connie J. Eaves: Quantitative Studies of Normal and Leukemic Stem Cells: Definition and Regulation8. Jean C.Y. Wang, Craig Dorrell, Caryn Y. Ito, Takeshi Inamitsu, Guillermo Guenechea, Olga I. Gan, and John E. Dick: Normal and Leukemic Human Stem Cells Assayed in Immune-Deficient Mice9. Catherine M. Verifaille: Ex Vivo Expansion of Hematopoietic Stem Cells10. David M. Bodine: Hematopoietic Stem Cell Gene Therapy: Progress and ProspectsPart II Early Embryology and Ontogeny11. Shuo Lin: Zebrafish Hematopoietic Development12. Todd Evans: Blood Formation During Xenopus Embryogenesis13. Margaret H. Baron: Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis14. Shin-Ichi Nishikawa, Satomi Nishikawa, Stuart Fraser, Tesuhiro Fujimoto, Hisahiro Yoshida, Masanori Hirashima, and Minetaro Ogawa: Developmental Relationships of Hematopoietic Stem Cells and Endothelial Cells15. Mervin C. Yoder and James Palis: Ventral (Yolk Sac) Hematopoiesis in the Mouse16. James B. Turpen: Dorsal Hematopoiesis in Fish and Amphibians17. Francoise Dieterlen-Lievre, Luc Pardanaud, Aianna Caprioli, and Thierry Jaffredo: Non-Yolk Sac Hematopoietic Stem Cells: The Avian Paradigm18. Elaine Dzierzak and Robert Oostendorp: Hematopoietic Stem Cell Development in Mammals19. Ana Cumano, Isabelle Godin, Sylvie Delassus, Francoise Dieterlen-Lievre, and Vasco Barreto: Changes in Lymphoid Progenitor Populations During Mammalian Development20. Michael V. Wyles and Gabrielle Proetzel: Use of Embyronic Stem Cell In Vitro Differentiation in a Serum-Free Environment for Analysis of Mesoderm Formation and Hematopoietic Development21. Bernard Mathey-Prevot and Herve Agaisse: Drosophila HematopoiesisPart III Important Factors in Hematopoiesis22. Hal E. Broxmeyer: Regulation of Myelopoiesis as Assessed by Gene Deletion and Gene Transduction23. Takahiko Hara, Koh Nakayama, and Atsushi Miyajima: Hematopoietic Signal Transduction24. Jennifer Rhodes and Brian J. Druker: Jak-STAT Signal Transduction25. Gregg L. Semenza: Oxygen-Regulated Erythropoietin Gene Expression26. John Yu: Involvement of Activins and TGF-sss in Hematopoiesis27. Ronald Hoffman and David J. Van Den Berg: Wnts and Hematopoiesis28. Malcolm A.S. Moore, Wei Han, Qian Ye: Notch Signaling During Hematopoiesis29. Thalia Papayannopoulou: Very Late Activation/ss1 Integrins in Hematopoiesis30. Craig Gerard and Gregory LaRosa: Chemokines31. Stuart H. Orkin: Transcriptional Control During Erythroid and Megakaryocytic Development32. Thomas Graf: Transcription Factors that Induce Commitment of Multipotent Hematopoietic Progenitors: Lessons from the MEP System33. Claus Nerlov, Daniel G. Tenen, and Thomas Graf: Regulatory Interactions Between Transcription Factors and Their Role in Hematopoietic Lineage Determination34. Anton Bauer, Olivier Gandrillon, Jacques Samarut, and Hartmut Beug: Nuclear Receptors in Hematopoietic Development: Cooperation with Growth Factor Receptors in Regulation of Proliferation and Differentiation35. Richard Dahl, Renee D. Hackenmiller, and M. Celeste Simon: Ets Transcription Factor Mutations and Hematopoiesis36. H. Jeffrey Lawrence, et al.: Homeobox Gene Networks and the Regulation of HematopoiesisPart IV: Myeloid Biology37. Daniel G. Tenen: Myeloid Transcription Factors and Development38. Daniel J. Price, Jerome E. Groopman, and Hava Avraham: Megakaryocyte Signaling39. Stephen D. Nimer: Transcription Factors Active in Megakaryocyte Development40. Jonathan G. Drachman and Kenneth Kaushansky: The Role of the Thrombopoietin Receptor in Megakaryopoiesis41. Chris S. Lantz and Stephen J. Galli: Mast Cell and Basophil Development42. Stephen G. Emerson, Russell S. Taichman, and Scott Adams: The Role of Osteoblasts in Hematopoietic Stem Cell BiologyPart V: Lymphoid Biology43. Clair Kelley, et al.: Role of Ikaros Proteins in Lymphocyte Development and Function44. Chay T. Kuo and Jeffrey M. Leiden: Transcriptional Regulation of T Cell Development and Activation45. Jyoti Sen and Steven J. Burakoff: Signal Transduction in Thymus Development46. Laurie H. Glimscher, Ann M. Ranger, and I-Cheng Ho: Lineage Commitment of CD4D[+T Helper Lymphocytes47. Joachim L. Schultze and John G. Gribben: B Cell Development and Maturation48. Albert C. Shaw, et al.: Signal Transduction and Regulation of Antigen Receptor Gene Rearrangement During Early Lymphocyte Development49. Ann L. Miracle, et al.: The Phylogenetic Development of the Cells that Express, and Mechanisms that Diversify, Immunoglobulins and T-Cell Antigen ReceptorsPart VI: Genetics of Blood Formation50. Leonard I. Zon: Zebrafish Hematopoietic Mutants51. Luanne L. Peters and Jane E. Barker: Spontaneous and Targeted Mutations in Erythrocyte Membrane Skeleton Genes: Mouse Models of Hereditary Spherocytosis52. Colin A. Sieff: Human Bone Marrow Failure Syndromes53. Robert H. Broyles: Hemoglobin Switching and Developmental Changes in Erythropoietic Sites and Red Blood Cell Populations of Nonmammalian Vertebrates54. George Stamatoyannopoulos: Hemoglobin Switching55. David A. Williams: Dominant White Spotting and Steel Mutants in Hematopoiesis56. Chris T. Amemiya and Tohru Ikuta: Applications of Large-Insert Genomic Cloning to the Study of Hematopoiesis57. A. Thomas Look: Abberant Control of Cell Fate in the Leukemias and LymphomasPart VII Stroma58. Pierre Charbord: Microenvironmental Cell Populations Essential for the Support of Hematopoietic Stem Cells59. Pierre Charbord: Mediators Involved in the Control of Hematopoiesis by the Microenvironment60. Paul J. Simmons, Stan Gronthos, and Andrew C.W. Zannettino: The Development of Stromal Cells61. Christa E. MDu"ller-Sieburg: Mouse Genetics for the Analysis of Stem Cell BehaviorPart VIII: Vasculogenesis62. Mira C. Puri, William L. Stanford, and Alan Bernstein: Receptor Tyrosine Kinases in Endothelial and Hematopoietic Cell Development63. Kari Alitalo, et al.: Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis64. Shahin Rafii: Regulation of Hematopoiesis by Bone Marrow Microvascular Endothelium65. Leena Larttunen, et al.: Vascular Matrix and Disorders66. Samuel Davis, et al.: The Angiopoietins and How They Act Coordinately with Vascular Endothelial Growth Factors During Normal and Pathologic Angiogenesis