Hematopoietic Stem Cell Transplantation by Michael R. Bishop

Hematopoietic Stem Cell Transplantation

EditorMichael R. Bishop

Hardcover | December 4, 2008

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The field of hematopoietic stem cell transplantation has undergone both evolutionary and dramatic changes over the past 25 years. This is evident by the fact that the term hematopoietic stem cell transplantation has effectively replaced the older term, bone marrow transplantation, due to the diverse source of hematopoietic cells that are employed for transplantation. Some of the most significant advances in hematopoietic stem cell transplantation have occurred in the past decade, as our understanding of stem cell biology, hematopoiesis, and immunology have increased. Alternative sources of stem cells, including those from unrelated donors and cord blood, the utilization of less toxic non-myeloablative and reduced-intensity conditioning regimens prior to transplant, and significantly improved supportive care measures have made hematopoietic stem cell transplantation available to greater numbers of patients.At the same time there have been parallel advances in the treatments of malignancy, which has significantly altered the indications and the role of hematopoietic stem cell transplantation in these diseases, most notably chronic myelogenous leukemia.This book reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution. It reviews the current clinical indications for the diseases that hematopoietic stem cell transplantation is most commonly utilized. Additional chapters cover the most recent translational research which will affect our future understanding and practice of hematopoietic stem cell transplantation.

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Title:Hematopoietic Stem Cell TransplantationFormat:HardcoverDimensions:608 pages, 9.25 × 6.1 × 0 inPublished:December 4, 2008Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387785795

ISBN - 13:9780387785790

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Table of Contents

Principles and overview of allogeneic hematopoietic stem cell transplantation.- Principles and overview of autologous hematopoietic stem cell transplantation.- Natural killer cell activity and killer immunoglobulin-like receptors in hematopoietic stem cell transplantation.- Advancement and clinical implications of HLA typing in allogeneic hematopoietic stem cell transplantation.- Immunogenomics and proteomics in hematopoietic stem cell transplantation.- Clinical implications of immune reconstitution following autologous and allogeneic hematopoietic stem cell transplantation.- T-regulatory cells and T cell cytokines in hematopoietic stem cell transplantation.- Understanding and enhancing the graft-versus-leukemia effect after hematopoietic stem cell transplantation.- Non-myeloablative and reduced-intensity allogeneic hematopoietic stem cell transplantation.- Cord blood transplantation.- Bone marrow and peripheral blood stem cell transplantation from unrelated donors.- Biology and management of acute graft-versus-host disease.- Biology and management of chronic graft-versus-host disease.- Radio-immunoconjugates in hematopoietic stem cell transplantation.- Evolving indications for hematopoietic stem cell transplantation in multiple myeloma and other plasma cell disorders.- Role of hematopoietic stem cell transplantation in the treatment of non-Hodgkin's lymphomas.- Role of hematopoietic stem cell transplantation in the treatment of Hodgkin's disease.- Role of hematopoietic stem cell transplantation in acute myelogenous leukemia.- Role of hematopoietic stem cell transplantation in acute myelogenous leukemia.- Hematopoietic stem cell transplantation in the management of pediatric malignancies.- Cellular adoptive immunotherapy after autologous and allogeneic hematopoietic stem cell transplantation.- Improvements in the prevention and management of infectious complications after hematopoietic stem cell transplantation.