Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies by Robert K. HamatakeHepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies by Robert K. Hamatake

Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical Studies

EditorRobert K. Hamatake, Johnson Y. N. Lau

Paperback | November 9, 2010

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For volume 2:A broad-ranging collection of cutting-edge techniques for the study of HBV and HDV infections and for the development of therapies to treat them. In this second of two volumes, Immunology, Model Systems, and Clinical Studies, the authors focus on protocols for the study of host immune responses to infection, in vitro and in vivo models of infection, and the development of antivirals. Each fully tested protocol is described in step-by-step detail by an established expert in the field and includes a background introduction outlining the principle underlying the technique, equipment and reagent lists, and tips on troubleshooting and avoiding known pitfalls. An accompanying first volume, Detection, Genotypes, and Characterization, contains user-friendly protocols for the identification and quantification of viral markers, the detection and impact of viral variants, and the study of the viral life cycle.For both volumes:A broad-ranging collection of core techniques for the study of HBV and HDV infections and for the development of therapies to treat them. The first volume Detection, Genotypes, and Characterization, the authors focus on readily reproducible molecular methods for the identification and quantification of viral markers, the detection and impact of viral variants, and the study of the viral life cycle. The second volume, Immunology, Model Systems, and Clinical Studies, contains user-friendly protocols for the study of host immune responses to infection, in vitro and in vivo models of infection, and the development of antivirals. Each fully tested protocol is described in step-by-step detail by an established expert in the field and includes a background introduction outlining the principle underlying the technique, equipment and reagent lists, and tips on troubleshooting and avoiding known pitfalls. The set offers both new and experienced investigators an encyclopedic collection of powerful tools for studying HBV and HDV infections, an essential resource for finding new therapies to treat chronically infected patients.
Title:Hepatitis B and D Protocols: Volume 2: Immunology, Model Systems, and Clinical StudiesFormat:PaperbackDimensions:595 pagesPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737363X

ISBN - 13:9781617373633

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Table of Contents

Part I. Viral-Specific Immunological and Other Host ResponsesStudying Host Immune Responses Against Duck Hepatitis B Virus InfectionDarren S. Miller, Edward M. Bertram, Catherine A. Scougall, Ieva Kotlarski, and Allison R. JilbertMeasurement of Cell-Mediated Immune Response in WoodchucksStephan Menne and Paul J. CoteStudy of Liver-Specific Expression of Cytokines During Woodchuck Hepatitis Virus InfectionMengji Lu and Michael RoggendorfInduction of Anti-Hepatitis B Virus Immune Responses Through DNA ImmunizationMichael Geissler, Robert Weth, Christian F. Grimm, Dörte Ortmann, and Hubert E. BlumMonitoring Gene Expression Using DNA Microarrays During Hepatitis B Virus InfectionMichael R. Beard and Stephen LocarniniDetermination of Hepatitis B Virus-Specific CD8+ T-Cell Activity in the LiverMichelina Nascimbeni and Barbara RehermannDetermining the Precursor Frequency of HBV Nucleocapsid Antigen-Specific T CellsJennifer A. Waters and Howard C. ThomasDetection and Characterization of Virus-Specific CD8+ T Cells Using the Tetramer ApproachXiao-Song He and Harry B. GreenbergIn Vitro Analysis of Hepatitis B Virus Specific CD4+ T CellsShilpa Chokshi and Nikolai V. NaoumovInduction of Humoral and Cellular Immune Responses to Hepatitis Delta Virus Through DNA Immunizaiton in BALB/c MiceRen-Shiang Lee, Shih-Jer Hsu, Li-Rung Huang, Hui-Lin Wu, Shiou-Lin Lin, Ding-Shinn Chen, and Pei-Jer ChenPart II. In Vitro and In Vivo ModelsInfection of Primary Chimpanzee Hepatocytes with Recombinant Hepatitis D Virus Particles: A Surrogate Model for Hepatitis B VirusAzeneth Barrera and Robert E. LanfordStudy of the Endocytosis and Intracellular Localization of Subviral Particles of Hepatitis B Virus in Primary HepatocytesDieter Glebe and Wolfram H. GerlichThe Tupaia Model for the Study of Hepatitis B Virus: Direct Infection and HBV Genome Transduction of Primary Tupaia HepatocytesFritz von Weizsäcker, Josef Köck, Sabine MacNelly, Shaotang Ren, Hubert E. Blum, and Michael NassalDelivery of Hepatitis B Virus Therapeutic Agents Using Asialoglycoprotein Receptor-Based Liver-Specific TargetingMasayoshi Konishi, Catherine H. Wu, and George Y. WuWoodchuck Hepatitis Virus Hepatocyte Culture ModelsNorma D. Churchill and Tomasz I. MichalakDuck Hepatitis B Virus Primary Hepatocyte Culture ModelOlivier Hantz and Fabien ZoulimEnhancement of Infection of HepG2 Cells in Culture by Predigestion of Hepadnavirus with V8 ProteaseXuanyong Lu and Timothy M. BlockConstruction of Recombinant Adenoviruses that Produce Infectious Hepatitis B VirusMartin Sprinzl, Jérôme Dumortier, and Ulrike ProtzerBaculovirus-Mediated Gene Transfer for the Study of Hepatitis B VirusHarriet C. Isom, Ayman M. Abdelhamed, John P. Bilello, and Thomas G. MillerTransgenic Hepatitis B Virus Mouse Model in the Study of ChemotherapyJohn D. MorreyTransplantation of Human Hepatocytes in Immunodeficient UPA Mice: A Model for the Study of Hepatitis B VirusJörg Petersen, Martin R. Burda, Maura Dandri, and Charles E. RoglerDuck Hepatitis B Virus Model in the Study of Hepatitis B VirusLucyna Cova and Fabien ZoulimHepatitis B Virus Transgenic Severe Combined Immunodeficient Mouse Model of Acute and Chronic Liver DiseaseMark A. Feitelson, Jonathan D. Larkin, and Raymond F. SchinaziThe Chimpanzee Model: Contributions and Considerations for Studies of Hepatitis B VirusPascal Gagneux and Elaine A. MuchmoreHepatitis B in Liver Transplant Recipients as a Special Model of Antiviral Drug DevelopmentRobert G. Gish and Adil WakilHepatitis Delta Virus Transfection for the Mouse In Vivo ModelJinhong Chang, Anthony Lerro, and John M. TaylorHepatitis Delta Virus RNA Transfection for the Cell Culture ModelThomas B. Macnaughton and Michael M. C. LaiPart III. Antiviral Testing and Clinical StudiesAnalysis of Hepatitis B Virus Dynamics and Its Impact on Antiviral DevelopmentManuel Tsiang and Craig S. GibbsGenotyping Anti-Hepatitis B Virus Drug ResistanceEric J. Bourne, Josée Gauthier, Vincent A. Lopez, and Lynn D. CondreayA Parsimonious Method for Screening Drug Combinations for Antihepadnaviral Activity Using a Parametric Dose-Response Surface ApproachTim Shaw and Stephen LocarniniHepatitis B Virus: Where Are We and Where Are We Going?Michael P. Manns, Johannes Hadem, and Heiner WedemeyerDesigning Studies to Evaluate Anti-Hepatitis B Virus Therapies: From the Perspective of Studies for the Registration of Pharmaceutical ProductsAlison B. MurraySpecific Considerations in the Design of Hepatitis B Virus Clinical Studies in the Far EastMan-Fung Yuen and Ching-Lung LaiStudying the Treatment of Chronic Hepatitis B Viral Infection in Special PopulationsRobert G. Gish and Stephen LocarniniDesigning Clinical Development Programs for Anti-Hepatitis B Virus DrugsNathaniel A. BrownTesting Antivirals Against Hepatitis Delta Virus: Farnesyl Transferase InhibitorsBruno B. Bordier and Jeffrey S. GlennIndex

Editorial Reviews

"Both volumes provide an excellent reference for background information and detailed experimental investigations for both Hepatitis B and Hepatitis D. A major attribute of the volumes is that as they cover a wide range of subjects, the reader has the opportunity to access information they would not normally encounter. Volumes 1 and 2 are an excellent reference source and the methodologies described present the opportunity for both new and experienced researchers to study the molecular aspects of HBV and HDV infection."-SGM Quarterly"...an excellent reference for background information and detailed experimental investigations for both Hepatitis B and Hepatitis D..." - Microbiology Today