Hepatocellular Carcinoma: Diagnosis And Treatment by Brian I. CarrHepatocellular Carcinoma: Diagnosis And Treatment by Brian I. Carr

Hepatocellular Carcinoma: Diagnosis And Treatment

byBrian I. Carr

Paperback | June 12, 2018

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• Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. 

"This is a well written text and should be a good reference book for those who see patients with HCC.." - Practical Gastroenterology

"...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC." - Digestive and Liver Disease
Dr. Brian I. Carr is Professor of Medical Oncology, Thomas Jefferson University, Philadelphia and Professor, IRCCS de Bellis, National Institute for Digestive Diseases, Castellana Grotte (BA), Italy. Since 1977 he has devoted both his clinical activities and research science efforts to the clinical and scientific study of primary liver...
Title:Hepatocellular Carcinoma: Diagnosis And TreatmentFormat:PaperbackDimensions:596 pagesPublished:June 12, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319817051

ISBN - 13:9783319817057


Table of Contents

Part A. Causes, Biological and Molecular bases of HCC

Chapter 1. Epidemiology of Hepatocellular Carcinoma - Donna L. White, Fasiha Kanwal, Li Jiao and Hashem B. El-Serag

Chapter 2. Environmental Carcinogens and Risk for Human Liver Cancer - John D. Groopman

Chapter 3. Molecular Mechanisms of Hepatocellular Carcinoma - Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal and Mehmet Ozturk

Chapter 4. Chemically-Induced Hepatocarcinogenesis - Yvonne P. Dragan

Chapter 5. Molecular Profiling of Human Hepatocellular Carcinoma - Anuradha Budhu and Xin Wei Wang

Chapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes - Jean-Charles Nault and Jessica Zucman-Rossi 

Chapter 7. MicroRNAs and hepatocellular carcinoma - Aldo Cavallini

Chapter 8. Non-tumor prognostic factors in hepatocellular carcinoma - Nicolas Goossens, Ismail Labgaa and Augusto Villanueva         

Chapter 9. Gut microbiota and HCC - Sven H. Loosen, Christoph Roderburg and Tom Luedde

Chapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer - Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna and Brian I. Carr

Chapter 11. HCC and its Microenvironment - Brian I. Carr

Chapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications - Zhengfen Yin

Chapter 13.  Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies - Tobias Flecken and Robert Thimme

Chapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma - Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva and Vladimir M. Perelmuter
Chapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma - David J. Pinato and Rohini Sharma

Chapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus - Inbal Houri and Oren Shibolet

Chapter 18. Obesity, NASH and HCC - Chadia L. Robertson, Devanand Sarkar and Arun J. Sanyal

Chapter 19. Metabolic Disease and Hepatocellular Carcinoma - David H. Van Thiel, Salamah Mohammad Alwahsh and Giuliano Ramadori

Part B. Diagnosis
Chapter 20. Pathologic Aspects of Hepatocellular Tumors - Michael A. Nalesnik 

Chapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches - Philip Johnson and Sarah Berhane

Chapter 22. Surveillance for hepatocellular carcinoma - Cristina Della Corte and Massimo Colombo

Chapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma - Satoshi Goshima

Chapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement - Tae Kyoung Kim, Hyun-Jung Jang and Stephanie R. Wilson

Chapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma - Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh and Donald G. Mitchell

Chapter 26. Computed Tomography of HCC - Francesco Agnello and Giuseppe Brancatelli

Chapter 27. Clinical features and clinician's diagnostic approach to hepatocellular carcinoma - Tamar Thurm and Oren Shibolet

Chapter 28. Current HCC Staging systems: their uses and limitations - Yukio Tokumitsu and Hiroaki Nagano

Part C. Therapies

Chapter 29. Percutaneous Ethanol Injection - Tito Livraghi, Maria Franca Meloni and Anita Andreano

Chapter 30. Thermal Ablative Treatments For Hepatocellular Carcinoma - Antonio Facciorusso and Michele Barone

Chapter 31. Resection of Hepatocellular Carcinoma - Nir Lubezky, Yaacov Goykhman, Richard Nakache and Ido Nachmany
Chapter 32. Liver Transplantation for Hepatocellular Carcinoma - Georg Györi, Pierre-Alain Clavien and Mickaël Lesurtel

Chapter 33. Medical Therapy of HCC - Brian I. Carr, Srikanth Nagalla and Ravit Geva             

Chapter 34. Targeted therapies for Hepatocellular Carcinoma - Susan Kralian and Brian I. Carr

Chapter 35. Radiation Therapy for Hepatocellular Carcinoma - Andrew S. Kennedy       

Chapter 36. Psychosocial Issues in Hepatocellular carcinoma - Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini and Mary A. Dew

Chapter 37. Bringing it all together - Brian I. Carr