High Throughput Screening for Novel Anti-Inflammatories by Michael KahnHigh Throughput Screening for Novel Anti-Inflammatories by Michael Kahn

High Throughput Screening for Novel Anti-Inflammatories

byMichael Kahn

Paperback | November 1, 2012

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Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.
Title:High Throughput Screening for Novel Anti-InflammatoriesFormat:PaperbackDimensions:258 pagesPublished:November 1, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:303489578X

ISBN - 13:9783034895781

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Table of Contents

Solid phase synthesis: Applications to combinatorial libraries.- Proteasome inhibitors.- Caspase-1 (ICE) and other caspases as drug discovery targets: Opportunities and progress.- Elastase inhibitors.- A high throughput assay for the TNF converting enzyme.- Tryptase inhibitors.- Selectin antagonists.- Cell adhesion integrins as pharmaceutical targets.- Inhibitors of the MAPK pathway.- Inhibition of NF-?B.- IL-1 antagonist discovery.- Phosphodiesterase inhibitors for respiratory diseases.