HIV: A Practical Approach Volume 1: Virology and Immunology: Hiv V01

Paperback | September 1, 1995

EditorJonathan KarnAs told byJonathan Karn

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AIDS is one of the most pressing medical emergencies of our era. Despite arguments to the contrary, the majority of AIDS researchers have agreed that there is a causal link between HIV infections and AIDS. However, it is now 12 years since the discovery of HIV and we are still a long wayfrom understanding and controlling AIDS HIV 1 and HIV 2 are guides to studying HIV in the laboratory. HIV 1 describes studies of the virus and infected cells and covers techniques for handling HIV safely, for studying viral entry, replication, and neutralization, and basic immunological techniques. HIV 2 explores the biochemistry and molecular biology of HIV, with a section on recent approaches to drug discovery.HIV research is highly multidisciplinary so a complete compendium of all related methods would have been unreadable. Instead, these two volumes focues on the specialized techniques which are unique to studies of HIV. The books have been designed so that a novice entering HIV research can findclear instructions about how to perform standard experiments, such as assays for reverse transcriptase or antibodies to HIV. In addition the books include many novel methods which are described in detail for the first time.

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From the Publisher

AIDS is one of the most pressing medical emergencies of our era. Despite arguments to the contrary, the majority of AIDS researchers have agreed that there is a causal link between HIV infections and AIDS. However, it is now 12 years since the discovery of HIV and we are still a long wayfrom understanding and controlling AIDS HIV 1 a...

J. Karn is at MRC Laboratory of Molecular Biology, Cambridge.
Format:PaperbackPublished:September 1, 1995Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199634920

ISBN - 13:9780199634927

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Table of Contents

Section 1: Growth and isolation of HIV1. Biological safety when working with HIV2. Virological and molecular genetic techniques for studies of established HIV isolates3. Isolation and biological characterization of primary HIV isolates4. HIV infection of macrophages5. HIV infection of dendritic cells6. Vectors based on HIVSection 2: Analysis of HIV infection7. Quantitative assays for virus neutralization8. Detection of HIV entry into cells9. Detection of viral DNA by PCR10. Detection of viral RNA by PCR11. Sequence analysis of virus variability based on PCRSection 3: Immunology12. Humoral responses and detection during HIV infection13. Quantification of CD4-positive T lymphocytes14. CD-4 positive T-cell responses in HIV-1 infection15. Lymphokine responses to HIV infection16. HIV-1 specific cytotoxic T-lymphocyte responses and ADCC

Editorial Reviews

`The two volumes are of exceptional value for laboratory workers studying the many different aspects of HIV and HIV disease. At an affordable price, these two volumes provide a wealth of information on standard techniques and on more sophisticated approaches for the study of the interactionbetween cellular and viral proteins. It is a comprehensive manual which serves as a solid basis for all investigators who are exploring this complex virus and the complex pathogenesis of HIV disease. Prferably in the form of multiple copies, it deserves a place on the bookshelf of any laboratoryworking with HIV.'M.A. Koch, Zentralblatt fur Bakteriologie 1996