HIV Interactions with Host Cell Proteins by Paul SpearmanHIV Interactions with Host Cell Proteins by Paul Spearman

HIV Interactions with Host Cell Proteins

EditorPaul Spearman

Paperback | March 1, 2012

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The authors seek to understand the assembly process of human immunodeficiency virus (HIV) and to develop a vaccine that can effectively neutralize HIV. HIV assembly is a process directed by the viral Gag polyprotein. Gag is a myristoylated precursor protein that is translated in the cytoplasm and then traffics to the plasma membrane or to endosomal vesicles for assembly. The authors have recently described an interaction between Gag and the delta subunit of the AP-3 adaptor protein complex (1). The mechanism and structural basis for this interaction is now under intense study. Our hypothesis is that the AP-3 interaction is responsible for the trafficking of Gag to the multivesicular body (MVB) and that this event is part of a normal productive particle assembly pathway. The Vpu protein of HIV assists the virus assembly process through a poorly-defined mechanism. The authors have presented evidence that Vpu overcomes a host cell restriction to assembly (2). Vpu appears to act through interactions with the recycling pathways in the cell, rather than directly interacting with Gag (3). The nature of the host restriction to assembly that Vpu overcomes is a focus of our ongoing work.
Title:HIV Interactions with Host Cell ProteinsFormat:PaperbackDimensions:214 pagesPublished:March 1, 2012Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642261825

ISBN - 13:9783642261824

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Table of Contents

Preface.- Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.- Interactions of viral protein U (Vpu) with cellular factors.- TRIM5alpha.- Human Immunodeficiency virus type-1 Gag and host vesicular trafficking pathways.- The roles of tetraspanins in HIV-1 replication.- Imaging of HIV/host protein interactions.- Virological and cellular roles of the transcriptional coactivator LEDGF/p75.- Implications of Nef - host cell interactions in viral persistences and progression to AIDS.- Vpr and its interactions with cellular proteins.- Subject index.