Homeostatic Control of Brain Function

Hardcover | February 10, 2016

EditorDetlev Boison, Susan A. Masino

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Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss ofhomeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improvebrain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfullypromote better overall brain health.Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

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Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss ofhomeostasis becomes expressed as a diverse array ...

Detlev Boison is the Robert Stone Dow Chair of Neurology; the Director of Neurobiology Research; and the Director of Basic and Translational Research at the Legacy Research Institute. Susan A. Masino is the Vernon Roosa Professor of Applied Science; and a Professor of Neuroscience and Psychology at Trinity College

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Format:HardcoverDimensions:656 pages, 10.12 × 6.89 × 1.1 inPublished:February 10, 2016Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199322295

ISBN - 13:9780199322299

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Table of Contents

ProloguePart I: Homeostatic Regulators: Molecules and Ions1. Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells2. Homeostatic control of adenosine levels and functions in brain3. Glutamate homeostasis as a regulatory of neurotransmitter recycling and synaptic function)4. Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanismsPart II: Homeostatic Control: Systems, Cells and Organelles5. Role of astrocytes in sleep and epilepsy6. Neuron-astrocyte interactions7. Homeostatic synaptic scaling at central synapses8. Homeostatic role of heterosynaptic plasticity9. The Blood Brain Barrier10. Inflammation and immunomodulation in epilepsy and its comorbidities11. Neuroplasticity12. Epigenetics13. Adult neural stem cells and brain homeostasisPart III: Homeostatic Manipulators: Preventative and Restorative Opportunities14. Systems (network) pharmacology for brain functionality restoration15. Ketogenic diets, mitochondria, and neurological diseases16. Dietary manipulations17. Exercise18. Sleep19. Botanicals20. The role of acupuncture in nociception homeostasis21. Meditation22. Neurotrophic regulation in neurorestoration of brainPart IV: Homeostatic Therapies for Disease and Dysfunction23. Epilepsy24. Traumatic Brain Injury25. Adenosine and Alzheimer's Disease, a possible epigenetic link26. Brain homeostasis and Parkinson's Disease27. Brain homeostasis and addiction28. Anxiety and stress disorders29. Malignant brain cancer management with metabolic therapy30. Obesity and diabetes: Nature, nurture, and beyond31. Autism spectrum disorders and homeostasis

Editorial Reviews

"This is an excellent textbook geared for basic scientists studying the metabolic regulation of the brain and methods in which to positively affect metabolism. It is extremely thorough yet very readable, with detailed references and figures. The authors are experts in their fields of study.A must-read for any neuroscientists working in the field of metabolism." --Eric H. W. Kossoff, M.D., Professor, Neurology and Pediatrics, Medical Director, Ketogenic Diet Center, Director, Pediatric Neurology Residency Program, Johns Hopkins Hospital, Baltimore, MD