Hormones and Brain Plasticity

Hardcover | May 25, 2009

byLuis Miguel Garcia-Segura

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The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones,brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism. Garcia-Segura argues that hormones are indispensable for adequately adapting the endogenous neuroplastic activity of the brain to the incessant modifications in external and internal environments. Their regulation of neuroplastic events in a given moment predetermines new neuroplastic responses thatwill occur in the future, adapting brain reorganization to changing physiological and behavioral demands throughout the life of the organism. The cross-regulation of brain plasticity and hormones integrates information originated in multiple endocrine glands and body organs with information comingfrom the external world in conjunction with the previous history of the organism. Multiple hormonal signals act in concert to regulate the generation of morphological and functional changes in neural cells, as well as the replacement of neurons, glial, and endothelial cells in neural networks. Brainremodeling, in turn, is involved in controlling the activity of the endocrine glands and regulating hormonal secretions. This bidirectional adjustment of brain plasticity in response to hormonal inputs, and adjustment of hormonal concentrations in response to neuroplastic events are crucial formaintaining the stability of the inner milieu and for the generation of adequate behavioral responses in anticipation of--and in adaptation to--new social and environmental circumstances and life events, including pathological conditions.

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The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones,brain regions, and neuroplastic events, and als...

Luis M. Garcia-Segura is Research Professor and head of the department of functional and systems neurobiology at the Cajal Institute of the Spanish National Research Council (CSIC) in Madrid. He is internationally recognized by his pioneering studies on the actions of hormones in the regulation of brain plasticity.
Format:HardcoverDimensions:496 pages, 9.3 × 6.3 × 1.4 inPublished:May 25, 2009Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019532661X

ISBN - 13:9780195326611

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Table of Contents

Preface and Acknowledgements1. Hormones and the Mutable Brain2. Brain Plasticity Regulates Hormonal Homeodynamics3. Hormonal Influences on Brain Plasticity: I. Melatonin, Thyroid Hormones, and Corticosteroids4. Hormonal Influences on Brain Plasticity: II. Sex Hormones5. Hormonal Influences on Brain Plasticity: III. Peptidergic Hormones6. Life Stages, Hormones, and Brain Remodeling: Early Hormonal Influences on Brain Mutability7. Life Stages, Hormones, and Brain Remodeling: The Transition from Childhood to Adulthood8. Life Stages, Hormones, and Brain Remodeling: Adult Reproductive Life9. Life Stages, Hormones, and Brain Remodeling: Disease10. Life Stages, Hormones, and Brain Remodeling: AgingBibliographyIndex

Editorial Reviews

"The past decades have brought a deeper understanding of the tremendously complex effects that hormones exert on brain function. This book gives a comprehensive and complete overview of this expanding field of neurobiology, while remaining very readable and clear. The author, a prominentauthority in the field, gives an excellent overview of the very early discoveries, connects these to the exciting new findings and discusses the far-reaching implications of the data presented. The result is a book relevant to a broad readership: both graduate students and experienced neuroscientistwill equally benefit from its philosophical approach." --Arpad Parducz, Institute of Biophysics, Biological Research Center, Szeged, Hungary