Hot Topics in Neural Membrane Lipidology by Akhlaq A. FarooquiHot Topics in Neural Membrane Lipidology by Akhlaq A. Farooqui

Hot Topics in Neural Membrane Lipidology

byAkhlaq A. Farooqui

Paperback | October 6, 2010

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Glycerophospholipid and sphingolipid-derived lipid mediators facilitate the transfer of messages not only from one cell to another but also from one subcellular organelle to another. These molecules are not only components of neural membranes but also storage depots for lipid mediators. Information on the generation and involvement of lipid mediators in neurological disorders is scattered throughout the literature in the form of original papers and reviews. This book will provide readers with a comprehensive description of glycerophospholipid, sphingolipid and cholesterol-derived lipid mediators and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge and comprehensive information on lipid mediators in a manner that is useful not only to students and teachers but also to researchers and physicians. This monograph has 11 chapters. Chapters 1 and 2 describe the generation of various lipid mediators from neural membrane glycerophospholipids, sphingolipids, and cholesterol, and their involvement and roles in signal transduction processes. Chapters 3 and 4 describe cutting edge information on roles of various isoforms and paralogs of phospholipases A2 in the generation of glycerophospholipid-derived lipid mediators and interactions among phospholipases A2, C, and D in the nucleus. Chapter 5 describes metabolism and roles of bioactive ether lipids in brain. Chapters 6 and 7 are devoted to excitotoxicity-mediated modulation of lipid mediators in neurological disorders and recent developments in kainic acid-induced neurotoxicity. Chapters 8 and 9 describe the health benefits of n-3 fatty acids (docosahexaenoic and eicosapentaenoic acids) in diet, the mechanisms of their action in cardiovascular and cerebrovascular systems, and comparison of n-3 fatty acid's effect with cholesterol lowering drugs (statins). Chapter 10 describes the contribution of neural membrane lipids in apoptosis and necrosis. Finally, Chapter 11 provides readers and researchers with a perspective that will be important for future research work on bioactive lipid mediators. This book will be particularly accessible to neuroscience graduate students and teachers, as well as researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in neurodegeneration in acute neural trauma (stroke, spinal cord trauma and head injury) and neurodegenerative diseases (Alzheimer disease, Parkinson disease, and Huntington disease). This monograph will be the first to provide a comprehensive description of glycerophospholipid, sphingolipid, and cholesterol-derived mediators, their interactions with each other in normal brain and in brain tissue from neurological disorders.
About the Author: Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 activity in brains from patients with Alzheimer disease, and published cutting edge research on th...
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Title:Hot Topics in Neural Membrane LipidologyFormat:PaperbackDimensions:408 pagesPublished:October 6, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441918825

ISBN - 13:9781441918826

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Table of Contents

Neural Membranes: A Pandora's Box of Lipid Mediators.- Interplay among glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in brain: a matter of life and death.- Janus face of phospholipase A2: role of phospholipase A2 in neural cell survival and death.- Glycerophospholipid metabolism in the nucleus: cross talk among phospholipase A2, phospholipase C and phospholipase D.- Ether glycerophospholipids: the workhorse lipids of neural membranes.- Excitotoxicity-mediated neurochemical changes in neurological disorders.- Recent developments on kainate-mediated neurotoxicity and their association with generation of lipid mediators.- Beneficial effects of docosahexaenoic acid on health of the human brain.- Effects of statins and n-3 fatty acids on heart and brain tissues: The clash of the titans.- Apoptosis and necrosis in brain: contribution of glycerophospholipid, sphingolipid and cholesterol-derived lipid mediators.- Perspective and directions for future developments on glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators.