Hox Genes: Studies from the 20th to the 21st Century by Jean S. DeutschHox Genes: Studies from the 20th to the 21st Century by Jean S. Deutsch

Hox Genes: Studies from the 20th to the 21st Century

byJean S. Deutsch

Hardcover | May 27, 2010

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The purpose of this book is to argue, and to convince those who may not agree, that the Hox genes are indeed so important that their study will not end with the 20th century. The book is divided into three major sections. The first section covers aspects of the regulation of Hox gene expression and the structure and function of the now justifiably well-known homeobox. The second section offers insights and discussions of the sometimes contentious issues of the origin and evolution of the aforementioned Hox complexes. In the third and last section the role of the resident loci in the specification of body plans and meristic identity of thearthropods is presented.
JEAN S. DEUT SCH, is Emeritus Professor of Genetics and Animal Biology, Université Pierre et Marie Curie, Paris 6, Department (UMR 7622) "Biologie du Développement". Under the supervision of Prof. P.P. Slonimski, he participated to the birth of mitochondrial genetics of the yeast Saccharomyces cerevisiae. During the '80s, he moved to t...
Title:Hox Genes: Studies from the 20th to the 21st CenturyFormat:HardcoverDimensions:169 pagesPublished:May 27, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441966722

ISBN - 13:9781441966728


Table of Contents

Section I. Mechanisms of Activity1. Regulation of Hox Activity: Insights from Protein MotifsSamir Merabet, Nagraj Sambrani, Jacques Pradel and Yacine GrabaAbstractIntroductionThe HomeodomainThe Hexapeptide MotifAdditional Hox Functional MotifsConclusion2. Cis-Regulation in the Drosophila Bithorax ComplexRobert K. Maeda and François KarchAbstractGenetics of the Bithorax Complex: The Model of Ed LewisThe BX-C Encodes Only Three Genes, Ubx, abd-A and Abd-BThe Segment-Specific Functions Act as Segment/Parasegment-Specific EnhancersInitiation and Maintenance Phase in BX-C RegulationInitiation, Maintenance and Cell Type-Specific Elements within the Cis-Regulatory DomainThe Cis-Regulatory Regions Are Organized in Segment-SpecificChromosomal DomainsChromatin Boundaries Flank the Parasegment-Specific DomainsElements Mediating Long-Distance Cis- and Trans- Regulatory InteractionsTransvection StudiesPromoter Targeting SequencesPromoter Tethering ElementIntergenic Transcription in the BX-CMicroRNAs in the BX-CConclusion3. Maintenance of Hox Gene Expression PatternsSamantha Beck, Floria Faradji, Hugh Brock and Frédérique PeronnetAbstractIntroductionGenetics of PcG and trxG GenesPcG Proteins and their ComplexesTrxG Proteins and Their ComplexesETP ProteinsPcG and trxG Response ElementsRecruitment of Maintenance Proteins to Maintenance ElementsRole of Maintenance Proteins in Regulation of TranscriptionEpigenetic MarksRelease of PcG SilencingRole of PcG proteins in Chromatin ReplicationRole of PcG Proteins in Stem CellsFuture Research in the Field4. Control of Vertebrate Hox Clusters by Remote and Global Cis-Acting Regulatory SequencesFrançois SpitzAbstractIntroductionColinearity and Clustering of the Homeotic Genes: An Obligatory Functional Link?Vertebrate Hox Clusters are More Clustered Than OthersGlobal Regulation of the Complex through Shared Mechanisms: The Retinoic Acid ConnectionHigh-Order Structures Over the Complex and ColinearityControl of Vertebrate Hox Genes by Shared Internal EnhancersThe Ins and Outs of Hoxd Gene RegulationThe Role of the Flanking Regions in the Control of Vertebrate Hox GenesControl of the HoxD Cluster through Remote EnhancersRegulation of the HoxD Cluster and More: Global Control Regions and Regulatory LandscapesRemote Enhancers for the Other Vertebrate Hox Clusters?An Evolutionary Success Story and an Increasing Need for a Global RegulationConclusion and Outlook for Hox Gene Regulation in the 21st CenturySection II. Evolution of Hox Genes and Complexes5. The Early Evolution of Hox Genes: A Battle of Belief?Bernd Schierwater and Kai KammAbstractThe Hox SystemPhylogenetic EvidenceOpposing ViewsConclusion6. Evolution of Hox ComplexesDavid E.K. FerrierAbstractIntroductionOrigin of the ProtoHox GeneOrigin of the Hox Cluster from a ProtoHox Cluster, or Not?Expansion and Contraction of the Number of Hox Genes in EvolutionConclusion7. The Nematode Story: Hox Gene Loss and Rapid EvolutionAziz Aboobaker and Mark BlaxterAbstract Introduction: Hox Gene Loss, the Third WayThe Caenorhabditis elegans Hox Cluster, an Extreme Case of Gene LossTracing Hox Gene Loss through the Nematode Phylum: Mode and TempoSea Squirts and Nematodes: Why Do Both Groups Lose Hox GenesHox Gene Loss in FlagranteNematode Hox Gene Function: A Story of Novelty, Conservation and RedeploymentConclusion8. Are the Deuterostome Posterior Hox Genes a Fast-Evolving Clas?Robert LanfearAbstractThe Distribution of the Posterior Hox genes in the MetazoaEarly Duplications of the Posterior Hox GenesThe 'Deuterostome Posterior Flexibility' HypothesisThe Mechanistic Basis of Deuterostome Posterior FlexibilityConclusion and Future DirectionsSection III. Biological Function9. Hox Genes and the Body Plans of Chelicerates and PycnogonidsWim G.M. DamenAbstractArthropods, Mandibulates vs CheliceratesChelicerate Hox GenesChelicerate Hox Genes and the Chelicerate vs Mandibulate Body PlanHox Genes and the Enigmatic sea Spider Body PlanConclusion10. Hox3/zen and the Evolution of Extraembryonic Epithelia in InsectsUrs Schmidt-Ott, Ab. Matteen Rafiqi and Steffen LemkeAbstractIntroductionSetting the Stage: Morphological Evolution of Extraembryonic DevelopmentVariants of zen Expression and Function in Insects and Possible Morphological CorrelatesThe Amnioserosa Gene-Network in Evolutionary PerspectiveConclusion11. Hox Genes and Brain Development in DrosophilaHeinrich Reichert and Bruno BelloAbstractIntroductionExpression and Function of Hox Genes in Embryonic Brain DevelopmentGenetic Interactions between Hox Genes in Embryonic Brain DevelopmentHox Genes in Postembryonic Brain DevelopmentEvolutionary Conservation of Hox Gene Action in Brain DevelopmentConclusion12. Homeosis and Beyond. What Is the Function of the Hox Genes?Jean S. DeutschAbstractWhat Are the Hox Genes?The Hox Genes' ExplosionWhat Is the Function of a Gene?Hox Genes' Function at the Molecular and Cellular LevelsHox Genes and HomeosisHomeosis as a Differential FunctionHox Genes as 'Meta-Selector' GenesThe Hox Specificity ParadoxPosterior PrevalenceAn Evolutionary Paradox: Morphological Differentiation and the Hox RepertoireHox and Neuronal HomeosisMorphological Homeosis as a Derived PropertyWhy Does the 'Hox System' Make Sense?ConclusionIndex