Hsp90 In Cancer: Beyond The Usual Suspects by Jennifer IsaacsHsp90 In Cancer: Beyond The Usual Suspects by Jennifer Isaacs

Hsp90 In Cancer: Beyond The Usual Suspects

byJennifer IsaacsEditorLuke Whitesell

Hardcover | February 22, 2016

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Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in theAdvances in Cancer Researchseries, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

  • Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins
  • Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology
  • Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, USALuke Whitesell is a pediatric oncologist and senior research scientist at the Whitehead Institute. His clinical interests lie in the treatment of children with recurrent, refractory solid tumors. His laboratory efforts focus on the discovery and pre...
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Title:Hsp90 In Cancer: Beyond The Usual SuspectsFormat:HardcoverDimensions:288 pages, 9.41 × 7.24 × 0.98 inPublished:February 22, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128022906

ISBN - 13:9780128022900

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Reviews

Table of Contents

1. Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard
2. Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
Mark R. Woodford, Diana Dunn, Jonelle B. Miller,Sami Jamal, Len Neckers and Mehdi Mollapour
3. Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg
4. HSP90 in Cancer: Transcriptional Roles in the Nucleus
S. K. Calderwood and L. Neckers
5. Hsp90 as a Chaperone of the Epigenome: Insights and Opportunities for Cancer Therapy
Jennifer S. Isaacs
6. Emerging Roles of Extracellular Hsp90 in Cancer
Daniel Senh Wong and Daniel G. Jay
7. GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li
8. HSP90 and Immune Modulation in Cancer
Michael W. Graner
9. Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers
Daniel Jarosz

Editorial Reviews

"This classic and essential series presents critical overviews on select aspects of both cancer
research and the basic underlying sciences.? -AMERICAN SCIENTIST
"Excellent, highly informative, in-depth reviews.expertly written, up-to-date, and
well-referenced.? -JOURNAL OF MEDICINAL CHEMISTRY
"This is a series that has a long tradition of excellence in the field of cancer biology.?
-DOODY'S PUBLISHING REVIEWS