Human Brain Proteome

Other | December 1, 2004

byNeuhold, Lisa A., Lisa A. Neuhold

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Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer's disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.

* Describes the latest databases and techniques for analyzing the data generated by proteomics
* Outlines the latest developments in proteomic methods
* Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers

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From the Publisher

Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biote...

Format:OtherDimensions:352 pages, 1 × 1 × 1 inPublished:December 1, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080522467

ISBN - 13:9780080522463

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Table of Contents

Section I:
High-Throughput Technologies
Biomarker Discovery Using Molecular Profiling Approaches
Proteomic Analysis of Mitochondrial Proteins
Section II:
Proteomic Applications
NMDA Receptors, Neural Pathways and Protein Interaction Databases
Dopamine Transporter Networks and Pathways
Proteomic Approaches in Drug Discovery and Development
Section III:
Informatics
Proteomic Informatics
Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration
Proteomics and Alcoholism
Proteomic Studies of Traumatic Brain Injury
Influence of Huntington's Disease on the Human and Mouse Proteome
Section V:
Overview of the Neuroproteome
Proteomics - Application to the Brain