Human Chromosomes

Paperback | October 6, 2000

byOrlando J. Miller, Eeva Therman

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The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.

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The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chrom...

Format:PaperbackDimensions:518 pages, 10 × 7.01 × 0.27 inPublished:October 6, 2000Language:English

The following ISBNs are associated with this title:

ISBN - 10:038795046X

ISBN - 13:9780387950464

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Table of Contents

From the contents: Preface.- Origins and Directions of Human Cytogenetics.- The Mitotic Cell Cycle and Chromosome Reproduction.- General Features of Mitotic Chromosomes.- The Chemistry and Packaging of Chromosomes.- Chromosome Bands.- Molecular Correlates of Chromosome Bands.- In situ Hybridization.- Somatic Cell Hybridization in Cytogenetic Analysis.- Main Features of Meiosis.- Details of Meiosis.- Meiotic Abnormalities: Abnormal Numbers of Chromosomes.- Abnormal Phenotypes due to Autosomal Aneuploidy.- Phenotypic Effects of Sex Chromosome Imbalance.- Sex Determination and the Y-chromosome.- The X Chromosome, Dosage Compensation, and X-inactivation.- Euploid Chromosome Aberrations, Uniparental Dsomy, and Imprinting.- Chromosome Changes During Cell Differentiation.- Chromosomal Structural Aberrations.- Abnormal Phenotypes Due to Autosomal Duplications and Deletions.- Structural Aberrations Involving Two or More Chromosomes.- Clinical Importance of Translocations and Inversions.- Chromosome Instability Syndromes.- Sister Chromatid Exchanges and Mitotic Crossing-Over.- Genome Instability and Multistep Carcinogenesis.- Chromosomes and Cancer. And much more...

Editorial Reviews

From the reviews of the third edition                                   "Each word "tells" in this concise gem of a human cytogenetics text...Superb organization makes this an excellent text...for any cytogenetics course."- American Journal of Human Genetics"...the leading textbook in English on human cytogenetics."- Cell