Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to…

Hardcover | February 3, 2010

EditorMuin J. Khoury, Sara R. Bedrosian, Marta Gwinn

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The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving healthand preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specificapplications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find thebook a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

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The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving healthand preventing disease. Since that time, ad...

Muin J. Khoury, MD, PhD, is Director of the Office of Public Health Genomics at the Centers for Disease Control and Prevention. He is an Adjunct Professor of Epidemiology at the Rollins School of Public Health at Emory University and an Associate in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health. Sar...

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Format:HardcoverDimensions:704 pages, 6.5 × 9.21 × 1.81 inPublished:February 3, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195398440

ISBN - 13:9780195398441

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Table of Contents

PART I: Fundamentals of human genome epidemiology revisited1. Muin J. Khoury, Sara R. Bedrosian, Marta L. Gwinn, Julian P. T. Higgins, John P. A. Ioannidis, and Julian Little: Human genome epidemiology: The road map revisited2. Jesus Gonzalez-Bosquet and Stephen Chanock: Principles of analysis of germline genetics3. Philippa Brice and Ron Zimmern: The public health genomics enterprise4. Marta L. Gwinn and Wei Yu: Navigating the evolving knowledge of human genetic variation in health and diseasePART II: Methods and approaches for data collection, analysis and integration5. Paul Burton, Isabel Fortier, and Bartha Knoppers: The global emergence of epidemiological biobanks: Opportunities and challenges6. Teri Manolio: Case-control and cohort studies in the age of genome-wide associations7. Daniela Seminara, Muin J. Khoury, Thomas R. O'Brien, Teri Manolio, Marta L. Gwinn, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein, Paolo Boffetta, Melissa Bondy, Molly S. Bray, Paul E. Brenchley, Patricia A. Buf?er, Juan Pablo Casas, Anand P. Chokkalingam, John Danesh, George DaveySmith, Siobhan Dolan, Ross Duncan, Nelleke A. Gruis, Mia Hashibe, David Hunter, Marjo-Riitta Jarvelin, Beatrice Malmer, Demetrius M. Maraganore, Julia A. Newton-Bishop, Elio Riboli, Georgia Salanti, Emanuela Taioli, Nic Timpson, Andre G. Uitterlinden, Paolo Vineis, Nick Wareham, Deborah M. Winn, RonZimmern, and John P. A. Ioannidis: The emergence of networks in human genome epidemiology: Challenges and opportunities8. Duncan Thomas: Design and analysis issues in genome-wide association studies9. Peter Kraft and David Hunter: The challenge of assessing complex gene-gene and gene-environment interactions10. Julian Little, Julian P.T. Higgins, John P.A. Ioannidis, David Moher, France Gagnon, Erik von Elm, Muin J. Khoury, Barbara Cohen, George Davey-Smith, Jeremy Grimshaw, Paul Scheet, Marta Gwinn, Robin E. Williamson, Guang Yong Zou, Kim Hutchings, Candice Y. Johnson, Valerie Tait, Miriam Wiens,Jean Golding, Cornelia van Duijn, John McLaughlin, Andrew Paterson, George Wells, Isabel Fortier, Matthew Freedman, Maja Zecevic, Richard King, Claire Infante-Rivard, Alex Stewart, and Nick Birkett: STrengthening the REporting of Genetic Association Studies (STREGA) - An extension of the STROBEstatement11. Julian P.T. Higgins and Julian Little: Integration of the evidence on gene-disease associations: Methods of HuGE reviews12. Muin J. Khoury, Lars Bertram, Paolo Boffetta, Adam S.Butterworth, Stephen J. Chanock, Siobhan M. Dolan, Isabel Fortier, Montserrat Garcia-Closas, Marta L. Gwinn, Julian P. T. Higgins, A. Cecile J.W. Janssens, James Ostell, Ryan P. Owen, Roberta A. Pagon, Timothy R. Rebbeck, Nathaniel Rothman,Jonine L. Bernstein , Paul R. Burton, Harry Campbell, Anand P. Chokkalingam, Helena Furberg, Julian Little, Thomas R. O'Brien, Daniela Seminara, Paolo Vineis, Deborah M. Winn, Wei Yu, and John P.A. Ioannidis: Genome-wide association studies, field synopses and the development of the knowledge baseon genetic variation and human diseasePART III: Case studies: Cumulative assessment of the role of human genome variation in specific diseases13. Harry Campbell, Steven Hawken, Evropi Theodoratou, Alex Demarsh, Kimberley Hutchings, Candice Y. Johnson, Lindsey Masson, Linda Sharp, Valerie Tait, Julian Little: Colorectal cancer14. Anand P. Chokkalingam and Patricia A. Buffler: Childhood leukemias15. Jonine D. Figueroa, Montserrat Garcia-Closas, and Nathanial Rothman: Bladder cancer16. Mark McCarthy and Eleftheria Zeggini: Type 2 diabetes17. Andre G. Uitterlinden, Joyce B.J. van Meurs, and Fernando Rivadeneira: Osteoporosis18. Siobhan M. Dolan: Preterm birth19. Adam S. Butterworth, Julian P.T. Higgins, Nadeem Sarwar, and John Danesh: Coronary heart disease20. Lars Bertram: SchizophreniaPART IV: Applications of epidemiologic methods for using genetic information in medicine and public health21. George Davey-Smith and Shah Ebrahim: Mendelian randomization: The contribution to genetic epidemiology to elucidating environmentally modifiable causes of disease22. A. Cecile J. W. Janssens, Marta Gwinn, and Muin J. Khoury: A. Cecile J. W. Janssens, Marta Gwinn, and Muin J. Khoury23. Steven M. Teutsch, Linda A. Bradley, Glenn E. Palomaki, James E. Haddow, Margaret Piper, Ned Calonge, W. David Dotson, Michael P. Douglas, and Alfred O. Berg: The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: Methods of the EGAPP working group24. Jim M. Gudgeon, Glenn E. Palomaki, and Marc S. Williams: Rapid evidence-based reviews of genetic tests25. Saskia C. Sanderson , Christopher Wade, and Colleen M. McBride: Role of social and behavioral research in assessing the utility of genetic information26. Scott Grosse: Assessing the evidence for clinical utility in newborn screening27. David L. Veenstra: The role of epidemiology in assessing the potential clinical impact of pharmacogenomics28. Mukesh Verma: The human epigenome and cancer29. Rodolfo Valdez, Muin J. Khoury, and Paula W. Yoon: The use of family history in public health practice: the epidemiologic viewPART V: Case studies: Assessing the use of genetic information in practice for specific diseases30. Iris Grossman, Mugdha Thakur, and David B. Matchar: Cytochrome P450 testing in the treatment of depression31. Monica R. McClain , Glenn E. Palomaki, Margaret Piper, and James E. Haddow: A rapid ACCE review of CYP2C9 and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding32. Diana B. Petitti: Hereditary hemochromatosis: Population screening for gene mutations