Human Melanoma: From Basic Research to Clinical Application by Soldano FerroneHuman Melanoma: From Basic Research to Clinical Application by Soldano Ferrone

Human Melanoma: From Basic Research to Clinical Application

bySoldano Ferrone

Paperback | December 13, 2011

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Malignant melanoma is the focus of investigations which range from basic re­ search to clinical trials with conventional therapy and with biological response modifiers. The involvement of investigators with different backgrounds in combi­ nation with recent progress in biotechnology has facilitated the characterization of the antigenic profile of melanoma cells, the analysis of the structural and function­ al properties of melanoma-associated antigens, and the application of immuno­ diagnostic and immunotherapeutic approaches to melanoma. As a result, a large body of information about various aspects of melanoma has been rapidly accumu­ lated during the past few years. In organizing this book I aimed at providing a readily available source of infor­ mation on the current research in melanoma. To this end I invited investigators with active research programs to contribute chapters describing and discussing the significance of their most recent results. To facilitate the preparation of the manu­ scripts and to avoid duplicating other recently published books on melanoma, I discouraged the contributors from providing extensive reviews of the literature on the various topics. Although I made every effort to be as complete as possible in the selection of the contributors, while writing this preface I realized that I had overlooked at least three investigators whose work should have been included.
Title:Human Melanoma: From Basic Research to Clinical ApplicationFormat:PaperbackDimensions:557 pagesPublished:December 13, 2011Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642744982

ISBN - 13:9783642744983

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Table of Contents

Biology.- Growth Regulation in Normal and Malignant Melanocytes.- Gangliosides in Melanoma.- Analysis of Human Melanosome-Specific Antigen in Malignant Melanoma and Its Precursors.- Role of Melanosomal Antigen in Melanoma Regression and Depigmentation.- Immunology and Molecular Biology.- Cross-Species Melanoma Antigen.- Melanoma-Associated Antigens in Xiphophorus Fish.- Characterization of p97, a Human Melanoma-Associated Antigen, and Development of a Recombinant Vaccine for Melanoma.- Molecular Cloning of Genes That Specify Melanoma-Associated Antigens.- Melanoma Antigens and Their Association with Malignant Transformation and Tumor Progression.- Antibody-Mediated Modulation of Melanoma-Associated Antigens: Access of Monoclonal Antibodies into Melanoma Cells and Melanoma Tissue.- The Central Role of Cell Surface-Deposited C3b in Complement Susceptibility of Human Melanoma Cells.- Second Generation Monoclonal Antibodies to a Human Melanoma-Associated Proteoglycan.- Immunobiology of Ocular Malignant Melanoma.- Immunobiology of the Regional Lymph Nodes in Cutaneous Malignant Melanoma.- HLA Class II Antigens on Melanoma Cells.- HLA Class II Molecules: Form and Function in Melanocytic Tumor Progression.- Clinical and Pathological Aspects.- Clinical and Immunohistological Features of Uveal Melanomas.- The Familial Atypical Multiple Mole Melanoma Syndrome and Visceral Cancer.- Immunopathology of Melanoma with Monoclonal Antibodies.- Changes in the Tumor-Associated Inflammatory Infiltrates in the Course of Local and Systemic Progression of Cutaneous Melanoma.- Clinical Implications of Human Melanoma-Associated Antigens.- Prognostic Factors for Cutaneous Melanoma.- Immunoscintigraphy.- Clinical Pharmacology Studies with Murine Antimelanoma Monoclonal Antibodies.- Radioimaging of Melanoma with 99Tcm-labeled Monoclonal Antibodies.- Radioimaging in Patients with Melanoma.- Radioimmunoscintigraphy of Ocular Melanomas.- Monoclonal Antibodies as Immunomodulating Agents in the Treatment of Melanoma.- Therapy.- Immunotherapy of Melanoma with Monoclonal Antibody-Drug Conjugates.- Immunotoxins to a Human Melanoma-Associated Proteoglycan: Progress Towards the Second Generation.- Preclinical Development of Monoclonal Antibody Conjugates for Site-directed Therapy of Human Malignant Melanoma.- Antimelanoma Antibodies for Therapy.- Therapy of Neuroectodermal Tumors with Monoclonal Antibodies.- Active Specific and Passive Immunotherapy of Melanoma: Clinical and Experimental Investigations with Murine Monoclonal Antibodies.- Immunoregulation and Active Specific Immunization in Cancer Treatment.- Vaccine Immunotherapy of Melanoma.- Surgery and Melanoma.- Surgery of Primary Melanoma.