Huntingtons Disease

Hardcover | May 1, 2014

EditorGillian Bates, Sarah Tabrizi, Lesley Jones

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This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: * Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages * The genetics of Huntington's disease, including new information on its epidemiology discussions of new testing guidelines* Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry* The molecular biology of Huntington's disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntington's disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology* An updated description of the comprehensive care for Huntington's disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials.

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This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: * Clinica...

Professor Gillian Bates obtained her PhD from the University of London in 1987. Her postdoctoral work was conducted with Hans Lehrach at the ICRF on the cloning of the Huntington's disease gene. Her work has been at the forefront of Huntington's disease research since establishing her independent research programme in 1994. Professor...

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Format:HardcoverDimensions:640 pages, 10 × 7 × 0.98 inPublished:May 1, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199929149

ISBN - 13:9780199929146

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Table of Contents

Section 1: Clinical aspects of Huntington's disease1. Peter S. Harper: Huntington's Disease in a Historical Context2. Raymund A. C. Roos: Clinical Neurology of Huntington's disease3. David Craufurd and Julie Snowden: Neuropsychiatry and Neuropsychology4. Oliver W. J. Quarrell: Juvenile Huntington's disease5. Edward J. Wild and Sarah J. Tabrizi: Premanifest and Early Huntington's DiseaseSection 2: The genetics of Huntington's disease6. Cecile Cazeneuve and Alexandra Durr: Huntington's disease: genetic and molecular studies7. Chris Kay, Emily Fisher, Michael R. Hayden: The Epidemiology of Huntington's Disease8. Rhona MacLeod and Aad Tibben: Genetic Counselling and TestingSection 3: Neurobiology9. Henry J. Waldvogel, Eric H. Kim, Lynette J. Tippett, Jean-Paul G. Vonsattel, and Richard L. M. Faull: The Neuropathology of Huntington's Disease in the Human Brain10. Michael S. Levine, Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Veronique M. Andre: Altered Neuronal Circuitry in Huntington's DiseaseSection 4: The molecular biology of Huntington's disease11. Chiara Zuccato and Elena Cattaneo: The normal function of huntingtin12. Ronald Wetzel and Rakesh Mishra: Order, disorder, and conformational flux in the structural biology of Huntington's Disease13. Alis Hughes and Lesley Jones: Pathogenic mechanisms in Huntington's disease14. Jorien M. M. van der Burg, N. Ahmad Aziz, Maria Bjorkqvist: Peripheral pathology in Huntington's diseaseSection 5: Therapeutic interventions in Huntington's disease15. Martha A. Nance: Comprehensive care in Huntington's disease16. Gillian P. Bates and Christian Landles: Preclinical Experimental Therapeutics in Huntington's Disease17. Beth Borowsky and Cristina Sampaio: Experimental Therapeutics in Huntington's Disease: Moving Forward in Clinical Trials