Hydroxy-Pyridones As Antifungal Agents With Special Emphasis On Onychomycosis by Sam ShusterHydroxy-Pyridones As Antifungal Agents With Special Emphasis On Onychomycosis by Sam Shuster

Hydroxy-Pyridones As Antifungal Agents With Special Emphasis On Onychomycosis

bySam Shuster


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This book presents a series of papers on a special group of antifungal agents - the hydroxypyridones (e.g. Ciclopirox, Rilopirox, and Piroctone) given by international experts at conferences in Vancouver and Sydney. The action of this group of agents is unique. Hydroxypyridones are not only active against all relevant fungi, but they are active against dermato­ phytes, yeasts, moulds as well as gram positive and gram negative bacteria. They have an inhibitory effect on the lipoxygenase and cyclo-oxygenase path­ ways and, in vitro, exhibit fungicidal and even sporicidal activity. Ciclopirox is particularly able to penetrate keratin. These properties facilitate the treatment not only of tinea pedis caused by fungi but also of infections by gram negative bacteria. The special ability of Ciclopirox to penetrate keratin opens the door to an efficacious topical treat­ ment for onychomycosis, with a transungual drug delivery system specially adapted to infections of the nail organ. The absence of drug interactions and systemic side effects of this formulation is an appreciable advantage over the newer systemic therapies for onychomycosis. Papers are presented covering the mode of action, antimicrobial spectrum, pharmacological properties, penetration potential, clinical efficacy and the various indications for this group of drugs. They will enable the reader to as­ sess the advantage and disadvantage of this new therapeutic modality.
Title:Hydroxy-Pyridones As Antifungal Agents With Special Emphasis On OnychomycosisFormat:PaperbackDimensions:109 pages

The following ISBNs are associated with this title:

ISBN - 10:3540654941

ISBN - 13:9783540654940


Table of Contents

1 Hydroxy-Pyridones Outstanding Biological Properties.- 2 Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone.- 3 Can Ciclopirox Be Used as a Broad-Spectrum Anti-Infective Agent?.- 4 Studies of the Anti-Inflammatory Properties of Ciclopirox.- 5 Measurement of Ciclopirox Permeation Through Fingernail Models by Novel Spectroscopic Techniques.- 6 Dermatomycosis: A Multifactorial Disease.- 7 Efficacy of Topical Batrafen.- 8 Ciclopirox Gel Treatment of Scalp Seborrhoeic Dermatitis.- 9 Seborrhoeic Dermatitis and Dandruff, and Its Treatment With Ciclopirox Shampoo.- 10 Epidemiology of Mycological Infections in Children - in South America.- 11 Clinical Efficacy of Topical Ciclopirox Nail Lacquer: Double-Blind United States Studies on Onychomycosis.- 12 Dose Regimen Studies with Ciclopirox Nail Lacquer.- 13 Open Studies of Ciclopirox Nail Lacquer in Onychomycosis - A Review.- 14 Influence of Onychomycosis on the Quality of Life.- 15 Treatment of Onychomycosis: Pharmacoeconomic Aspects.- 16 The Safety Aspects of Systemic and Topical Antifungal Agents Used in the Management of Onychomycosis.- 17 Differential Diagnosis of Onychomycosis and Rationale for a Step-Therapy in Treating Nail Fungal Infection.