Hypertension: Methods and Protocols by Jérôme P. FennellHypertension: Methods and Protocols by Jérôme P. Fennell

Hypertension: Methods and Protocols

EditorJérôme P. Fennell, Andrew H. Baker

Paperback | November 10, 2010

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A collection of new and essential molecular techniques for cardiovascular research. These readily reproducible methods range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using nonviral (polymers, liposomes, and antisense agents) and adenoviral vectors. Additional techniques described include single nucleotide polymorphism (SNP) genotyping, RNA interference, microarray analysis, pharmacogenetics, and pharmacogenomics for the genetic dissection of hypertension, as well as a practical method for deriving cardiomyocytes from embryonic stem cells that would serve as replacement cells for those damaged by hypertension or heart attack. The book offers both novice and experienced hypertension researchers an indispensable collection of readily reproducible techniques for successful research, work that has already dramatically improved the outlook for hypertensive patients, and promises much future success.

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Title:Hypertension: Methods and ProtocolsFormat:PaperbackDimensions:518 pages, 9.02 × 5.98 × 0 inPublished:November 10, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374938

ISBN - 13:9781617374937

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Table of Contents

Part I. Models of HypertensionCongenic/Consomic Models of HypertensionDelyth Graham, Martin W. McBride, Nicholas J. R. Brain, and Anna F. DominiczakMouse Knockout Models of HypertensionMichael BaderProduction of Transgenic Models in HypertensionElena Popova, Michael Bader, and Alexander KrivokharchenkoMeasuring Blood Pressure in Small Laboratory AnimalsKlaas Kramer and René RemiePart II. Assessment of Free Radicals in Endothelial DysfunctionAnalysis of Superoxide Anion Production in TissueMichela Zanetti, Livius V. d'Uscio, Timothy E. Peterson, Zvonimir S. Katusic, and Timothy O'BrienMeasurement of Vascular Reactive Oxygen Species Production by ChemiluminescenceTomasz J. Guzik and Keith M. ChannonA Guide to Wire MyographyAngela Spiers and Neal PadmanabhanPart III. Nucleic Acid TechniquesSelection of Candidate Genes in HypertensionCharles A. Mein, Mark J. Caulfield, and Patricia B. MunroeGenome-Wide Scanning With SSLPs in the RatCarol Moreno, Kathleen Kennedy, Jaime Wendt Andrae, and Howard J. JacobExtraction of RNA From Cells and TissueIan M. BirdSingle-Strand Conformational Polymorphism Analysis: Basic Principles and Routine PracticeYanbin Dong and Haidong ZhuSingle-Nucleotide Polymorphism Genotyping for Disease Association StudiesMyriam Fornage and Peter A. DorisDenaturing High-Performance Liquid Chromatography Using the WAVE DNA Fragment Analysis SystemElizabeth DonohoeTaqMan Real-Time PCR Quantification: Conventional and Modified MethodsMichihiro Yoshimura, Shota Nakamura, and Hisao OgawaGeneration of High-Sensitivity Antisense cDNA Probes by Asymmetric PCRIan M. BirdNew Advances in Microarrays: Finding the Genes Causally Involved in DiseaseClaudio Napoli, Filomena de Nigris, and Vincenzo SicaPharmacogenetics and PharmacogenomicsKlaus LindpaintnerPart IV. Proteins and ProteomicsDetermination of the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine in Biological Samples by HPLCTom TeerlinkProteomic Approaches in the Analysis of HypertensionSoren Naaby-Hansen, Gayathri D. Warnasuriya, Claire Hastie, Piers Gallney, and Rainer CramerPart V. Gene TransferGene Transfer in Endothelial Dysfunction and HypertensionSabyasachi Sen, Padraig M. Strappe, and Timothy O'BrienNonviral Gene Delivery Methods in Cardiovascular DiseasesMarika Ruponen, Zanna Hyvönen, Arto Urtti, and Seppo Ylä-HerttualaConstruction and Characterization of Helper-Dependent Adenoviral Vectors for Sustained In Vivo Gene TherapyKazuhiro Oka and Lawrence ChanAdenovirus-Mediated Gene Transfer In Vivo: An Approach to Reduce Oxidative StressYi ChuGene Therapy for Hypertension: Antisense Inhibition of the Renin-Angiotensin SystemM. Ian Phillips and Birgitta KimuraModulation of Gene Expression by RNAiCezary Wójcik, Rosalind Fabunmi, and George N. DeMartinoIn Vivo Biopanning: A Methodological Approach to Identifying Novel Targeting Ligands for Delivery of Biological Agents to the VasculatureLorraine M. Work, Campbell G. Nicol, Laura Denby, and Andrew H. BakerPart VI. Stem CellsCardiomyocytes Derived From Embryonic Stem CellsKenneth R. Boheler, David G. Crider, Yelena Tarasova, and Victor A. MaltsevPart VII. BioinformaticsIn Silico and Wet-Bench Identification of Nuclear Matrix Attachment RegionsStephen A. Krawetz, Sorin Draghici, Robert Goodrich, Zhandong Liu, and G. Charles OstermeierBiomedical Informatics Methods in PharmacogenomicsQing YanIndex

Editorial Reviews

From the reviews:"This is an outstandingly interesting book..." - Biomedical Chromatography"This book of 29 chapters by 73 contributors is exclusively for researchers in hypertension." (American Journal of Cardiology, June, 2007)