IgM and Its Receptors and Binding Proteins by Hiromi KubagawaIgM and Its Receptors and Binding Proteins by Hiromi Kubagawa

IgM and Its Receptors and Binding Proteins

byHiromi KubagawaEditorPeter D. Burrows

Paperback | May 18, 2018

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This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, GermanyPeter D. Burrows, PhD, is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA
Title:IgM and Its Receptors and Binding ProteinsFormat:PaperbackDimensions:117 pagesPublished:May 18, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319878107

ISBN - 13:9783319878102


Table of Contents

The appearance and diversification of receptors for IgM during vertebrate evolution..- Authentic IgM Fc Receptor (FcμR).- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells.- Specific IgM and regulation of antibody responses.- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.