Illuminating Disease: An Introduction to Green Fluorescent Proteins

Hardcover | January 27, 2015

byMarc Zimmer

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Green fluorescent proteins have been floating in the ocean for more than 160 million years, but it took a curious scientist, fascinated by pinpricks of green light, to begin unlocking their potential. Now these jellyfish proteins have become one of the most important tools available toresearchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under a microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are used in over three millionexperiments a year and have proved invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existence of cancerous stem cells.In Illuminating Disease, Marc Zimmer introduces us to these revolutionary proteins, acquainting readers both with the researchers responsible for the proteins' discovery as well as their wide utility. The book details the history of genetically modified fluorescent parasites and viruses, whichprovide scientists with lifesaving information about the spread of diseases. Green fluorescent proteins allow scientists and doctors to understand diseases better by quite literally illuminating various microscopic interactions occurring in living cells that otherwise would have gone unseen.The book is richly illustrated, showing the visually striking uses of green fluorescent proteins, and many of these scans have won awards in biological imaging competitions. An ideal introduction for students and advanced researchers alike, Illuminating Disease is an accessible yet deeply probinginvestigation into one of the most important developments in medical research of the last several decades.

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Green fluorescent proteins have been floating in the ocean for more than 160 million years, but it took a curious scientist, fascinated by pinpricks of green light, to begin unlocking their potential. Now these jellyfish proteins have become one of the most important tools available toresearchers in modern medicine and biology. By usin...

Marc Zimmer is Professor of Chemistry at Connecticut College. He has published articles on science and medicine for the Los Angeles Times, USA Today, and the Huffington Post, among many other publications.

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Format:HardcoverDimensions:240 pages, 9.41 × 6.42 × 0.91 inPublished:January 27, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199362815

ISBN - 13:9780199362813

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Table of Contents

1. Introduction: Nature's Lights2. Malaria3. Dengue4. Swine and Bird Flu5. Chagas6. AIDS/HIV7. Cancer8. Heart9. Diseases of the Brain10. Optogenetics

Editorial Reviews

"For many years, GFP attracted keen attention of scientists because of its unique biochemistry and practical usefulness, and simply due to its aesthetic beauty. Dr. Zimmer describes a lot of facts of medicine and basic biology, but at the same time does not forget to explain all basics tonon-scientist readers, often suggesting surprising and illustrative parallels with everyday life. The book is full of stories of people who made key discoveries and technical breakthroughs in the field, and it shows an exciting flow of appearance and implementation of scientific ideas." --Sergey Lukyanov, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry